Article

Licochalcone A isolated from licorice suppresses lipopolysaccharide-stimulated inflammatory reactions in RAW264.7 cells and endotoxin shock in mice

Journal of Molecular Medicine (impact factor: 4.67). 04/2012; 86(11):1287-1295. DOI:10.1007/s00109-008-0395-2

ABSTRACT Licochalcone A (LicA), a major phenolic constituent of the licorice species Glycyrrhiza inflata, exhibits various biological properties, including chemopreventive, anti-bacterial, and anti-spasmodic activity. We report
that LicA inhibits inflammatory reactions in macrophages and protects mice from endotoxin shock. Our in vitro experiments
showed that LicA suppressed not only the generation of nitric oxide (NO) and prostaglandin (PG)E2, but also the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 induced by lipopolysaccharide
(LPS) in RAW264.7 cells. Similarly, LicA inhibited the production of inflammatory cytokines induced by LPS in RAW264.7 cells,
including IL-1β and IL-6. In an animal model, LicA protected BALB/c mice from LPS-induced endotoxin shock, possibly through
inhibiting the production of inflammatory cytokines and NO. Collectively, LicA inhibited the production of inflammatory mediators
and may be a potential target for treatment of various inflammatory diseases.

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Keywords

animal model
 
anti-spasmodic activity
 
chemopreventive
 
COX)-2 induced
 
endotoxin shock
 
exhibits various biological properties
 
IL-1β
 
IL-6
 
inducible nitric oxide synthase
 
inflammatory cytokines induced
 
inflammatory mediators
 
LicA
 
LicA inhibits inflammatory reactions
 
LicA suppressed
 
LPS-induced endotoxin shock
 
major phenolic constituent
 
nitric oxide
 
potential target
 
various inflammatory diseases
 
vitro experiments