Antiangiogenic therapy for breast cancer: current status and future perspectives

The Chinese-German Journal of Clinical Oncology 07/2011; 10(7):373-379. DOI: 10.1007/s10330-011-0812-9


Tumor angiogenesis plays an important role in the growth, invasion and metastasis of breast cancer, therefore recently a very
active area of breast cancer research involves the addition of antiangiogenic therapy. Numerous clinical studies for several
antiangiogenic agents have recently been conducted in breast cancer patients and have shown clinically significant improvement
in outcomes. This review gives a brief background to breast cancer angiogenesis, also focusing on current progress in the
field of antiangiogenic therapy for breast cancer and issues regarding future therapeutic development.

Key wordsbreast cancer–angiogenesis–antiangiogenic therapy–vascular endothelial growth factor (VEGF)–bevacizumab

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