I fattori di crescita e gli “scaffold” biologici nella chirurgia della cuffia dei rotatori

Università degli Studi di Milano, IRCCS Istituto Ortopedico Galeazzi Dipartimento di Tecnologie per la Vita, Facoltà di Medicina Milano Italy
LO SCALPELLO-OTODI Educational 10/2008; 22(1):66-76. DOI: 10.1007/s11639-008-0092-5

ABSTRACT Rotator cuff injuries are a common source of pain and an important cause of reduction of quality of life. In Italy, it is
estimated that 30% of individuals over 60 years of age experience rotator cuff injuries. Despite the advances in surgical
techniques, the rate of recurrent tears after surgical repair is high (up to 40%). Tendon healing forms lower quality tissue
and, despite remodelling the healed tendon’s tissue never matches that of intact tendon. Due to the frequency of these injuries,
as well as the rate of re-tear, it is not surprising that new and innovative strategies like tissue engineering have become
more appealing. Tissue engineering strategies involve the use of scaffolds, cells, and/or bioactive factors to promote tendon
regeneration via natural processes. The present paper reviews the current state of knowledge regarding regeneration of tendon’s
tissue from cells with the support of scaffolds and growth factors.

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