Diet in the epidemiology of endometrial cancer in Western New York (United States)
ABSTRACT Objectives: We examined diet and risk of endometrial cancer among women in the Western New York Diet Study (1986–1991).
Methods: Self-reported frequency of use of 172 foods and beverages during the 2 years before the interview and other relevant data were collected by detailed interviews from 232 endometrial cancer cases and 639 controls, frequency-matched for age and county of residence. Odds ratios (OR) and 95% confidence intervals (CI) were estimated by unconditional logistic regression, adjusting for age, education, body mass index (BMI), smoking history, hypertension, diabetes, age at menarche, parity, oral contraceptive use, menopausal status, menopausal estrogen use, and energy.
Results: Risks were reduced for women in the highest quartiles of intake of protein (OR 0.4, 95% CI: 0.2–0.9), dietary fiber (OR 0.5, 95% CI: 0.3–1.0), phytosterols (OR 0.6, 95% CI: 0.3–1.0), vitamin C (OR 0.5, 95% CI: 0.3–0.8) folate (OR 0.4, 95% CI: 0.2–0.7), alpha-carotene (OR 0.6, 95% CI: 0.4–1.0), beta-carotene (OR 0.4, 95% CI: 0.2–0.6), lycopene (OR 0.6, 95% CI: 0.4–1.0), lutein + zeaxanthin (OR 0.3, 95% CI: 0.2–0.5) and vegetables (OR 0.5, 95% CI: 0.3–0.9), but unrelated to energy (OR 0.9, 95% CI: 0.6–1.5) or fat (OR 1.6, 95% CI: 0.7–3.4).
Conclusions: Our results support previous findings of reduced endometrial cancer risks associated with a diet high in plant foods.
- SourceAvailable from: Adriano Decarli[Show abstract] [Hide abstract]
ABSTRACT: Background:Because of their antioxidant and antimutagenic properties, flavonoids may reduce cancer risk. Some flavonoids have antiestrogenic effects that can inhibit the growth and proliferation of endometrial cancer cells.Methods:In order to examine the relation between dietary flavonoids and endometrial cancer, we analysed data from an Italian case-control study including 454 incident, histologically confirmed endometrial cancers and 908 hospital-based controls. Information was collected through a validated food-frequency questionnaire. We applied data on food and beverage composition to estimate the intake of flavanols, flavanones, flavonols, anthocyanidins, flavones, isoflavones, and proanthocyanidins. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated from multiple logistic regression models conditioned on age and study centre and adjusted for major confounding factors.Results:Women in the highest quartile category of proanthocyanidins with 3 mers vs the first three quartile categories had an OR for endometrial cancer of 0.66 (95% CI=0.48-0.89). For no other class of flavonoids, a significant overall association was found. There was a suggestion of an inverse association for flavanones and isoflavones among women with body mass index <25 kg m(-2), and, for flavanones, among parous or non-users of hormone-replacement therapy women.Conclusion:High consumption of selected proanthocyanidins may reduce endometrial cancer risk.British Journal of Cancer advance online publication, 6 August 2013; doi:10.1038/bjc.2013.447 www.bjcancer.com.British Journal of Cancer 08/2013; 109(7). DOI:10.1038/bjc.2013.447 · 4.82 Impact Factor
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ABSTRACT: It has been proposed that folate and polymorphisms of the enzyme methylenetetrahydrofolate reductase (MTHFR), which regulates influx of folate for methylation reactions for DNA synthesis and repair, are involved in colorectal cancer. This study was designed to determine the influence of a genetic variant (MTHFR G1793A) and folate on colon cancer in Iran. We analyzed 227 cases and 239 normal unmatched controls using pyrosequencing. Odds ratios and 95% confidence intervals (95% CI) were calculated to evaluate associations of the MTHFR gene polymorphism with colorectal cancer risk. A significantly reduced risk of recurrence was observed in patients heterozygous for the MTHFR G1793A polymorphism (OR: 0.17; 95% CI, 0.05-0.52). The frequency of GG, GA and AA genotypes of MTHFR among the colorectal cancer patients were 98%, 2% and 0% respectively, while the frequencies among controls were 90%, 10% and 0%, respectively. Furthermore, a significant reduction in recurrence risk was seen in MTHFR G1793A heterozygotes limited to those who received folate supplements. Our study is compatible with previous findings concerning a reverse association between the MTHFR 1793G> A genotype with cancers in different populations.Asian Pacific journal of cancer prevention: APJCP 01/2008; 9(4):659-62. · 2.51 Impact Factor
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ABSTRACT: We evaluated animal food intake and cooking methods in relation to endometrial cancer risk in a population-based case-control study in Shanghai, China. A validated food frequency questionnaire was used to collect the usual dietary habits of 1204 cases and 1212 controls aged 30-69 years between 1997 and 2003. Statistical analyses were based on an unconditional logistic regression model adjusting for potential confounders. High intake of meat and fish was associated with an increased risk of endometrial cancer, with adjusted odds ratios for the highest vs the lowest quartile groups being 1.7 (95% confidence interval: 1.3-2.2) and 2.4 (1.8-3.1), respectively. The elevated risk was observed for all types of meat and fish intake. Intake of eggs and milk was not related to risk. Cooking methods and doneness levels for meat and fish were not associated with risk, nor did they modify the association with meat and fish consumption. Our study suggests that animal food consumption may play an important role in the aetiology of endometrial cancer, but cooking methods have minimal influence on risk among Chinese women.British Journal of Cancer 01/2007; 95(11):1586-92. DOI:10.1038/sj.bjc.6603458 · 4.82 Impact Factor