Article

LC Enantioseparation of β-Amino Acids on a Crown Ether-Based Stationary Phase

Chromatographia (impact factor: 1.2). 04/2012; 68:13-18. DOI:10.1365/s10337-007-0498-x pp.13-18

ABSTRACT Reversed-phase high-performance liquid chromatographic methods were developed for the enantioseparation of ten unusual β-3-homo-amino
acids. The underivatized analytes were separated on a chiral stationary phase containing (+)-(18-crown-6)-2,3,11,12-tetracarboxylic
acid as chiral selector. The effects of organic and acidic modifiers and the mobile phase composition on the separation were
investigated. The structures of the substituents in the β position substantially influenced the retention and resolution.
The elution sequence was determined in some cases: the S enantiomers eluted before the R enantiomers.

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Keywords

acidic modifiers
 
cases
 
chiral selector
 
chiral stationary phase
 
elution sequence
 
enantioseparation
 
mobile phase composition
 
R enantiomers
 
Reversed-phase high-performance liquid chromatographic methods
 
S enantiomers eluted
 
structures
 
substituents
 
underivatized analytes
 
β position