Helix induction potential of N-terminal α-methyl, α-amino acids

University of Padova
Letters in Peptide Science 04/1998; 5(2):105-107. DOI: 10.1023/A:1008873910529


A series of longer analogues of the C-peptide of RNAse A has been synthesized with the aim of assessing the helix induction potential in water of -methyl, -amino acids at the N-terminus of the chain. The circular dichroism data indicate that one isovaline residue is effective in increasing the helix content of the 13-residue peptide by about 7%.

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