Genetic analysis of a divergent selection for resistance to Rous sarcomas in chickens†. This article is dedicated to the memory of Pierrick Thoraval (1960–2000).

Genetics Selection Evolution (Impact Factor: 3.49). 01/2004; 36(1):1-17. DOI: 10.1186/1297-9686-36-1-65

ABSTRACT Selection for disease resistance related traits is a tool of choice for evidencing and exploring genetic variability and studying
underlying resistance mechanisms. In this framework, chickens originating from a base population, homozygote for the B
19 major histocompatibility complex (MHC) were divergently selected for either progression or regression of tumors induced at
4 weeks of age by a SR-D strain of Rous sarcoma virus (RSV). The first generation of selection was based on a progeny test
and subsequent selections were performed on full-sibs. Data of 18 generations including a total of 2010 birds measured were
analyzed for the tumor profile index (TPI), a synthetic criterion of resistance derived from recording the volume of the tumors
and mortality. Response to selection and heritability of TPI were estimated using a restricted maximum likelihood method with
an animal model. Significant progress was shown in both directions: the lines differing significantly for TPI and mortality
becoming null in the "regressor" line. Heritability of TPI was estimated as 0.49 ± 0.05 and 0.53 ± 0.06 within the progressor
and regressor lines respectively, and 0.46 ± 0.03 when estimated over lines. Preliminary results showed within the progressor
line a possible association between one Rfp-Y type and the growth of tumors.

chicken-selection-resistance-Rous sarcoma-
Rfp - Y

  • Pediatrics 11/1948; 2(4):469-79. · 5.12 Impact Factor
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    ABSTRACT: The fate of tumors induced by Rous sarcoma virus (RSV) was determined in anF2 population segregating at three alloantigen loci. TheF1 resulted from crossing tumor-resistant RPRL line 61 (B2B2D3D3I2I2) with tumor-susceptible RPRL line 151 (B5B5D4D4I8I8). Among theF2 segregantsB2B2,B2B5, andB5B5, the percentage of chicks dying of terminal tumors (by 70 days post-inoculation) was 5, 26, and 93, respectively (P?0.01). NeitherD orI genotypes nor sex significantly affected tumor growth. In chickens with terminal tumors, the incidence of metastatic lesions was also significantly associated withB genotypes. Thus, the MHC chromosomal region in the chicken appears to exert a crucial role in determining the outcome of RSV-induced tumors.
    Immunogenetics 01/1977; 5(1):333-343. · 2.89 Impact Factor
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    ABSTRACT: Analyses of the major histocompatibility complex (Mhc) in chickens have shown inconsistencies between serologically defined haplotypes and haplotypes defined by the restriction fragment patterns of Mhc class I and class II genes in Southern hybridizations. Often more than one pattern of restriction fragments for Mhc class I and/or class II genes has been found among DNA samples collected from birds homozygous for a single serologically defined B haplotype. Such findings have been interpreted as evidence for variability within the Mhc haplotypes of chickens not detected previously with serological methods. In this study of a fully pedigreed family over three generations, the heterogeneity observed in restriction fragment patterns was found to be the result of the presence of a second, independently segregating polymorphic Mhc-like locus, designated Rfp-Y. Three alleles (haplotypes) are identified in this new system.
    Immunogenetics 02/1993; 37(6):408-14. · 2.89 Impact Factor

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