Genetic analysis of a divergent selection for resistance to Rous sarcomas in chickens†. This article is dedicated to the memory of Pierrick Thoraval (1960–2000).

Genetics Selection Evolution (Impact Factor: 3.75). 01/2004; 36(1):1-17. DOI: 10.1186/1297-9686-36-1-65

ABSTRACT Selection for disease resistance related traits is a tool of choice for evidencing and exploring genetic variability and studying
underlying resistance mechanisms. In this framework, chickens originating from a base population, homozygote for the B
19 major histocompatibility complex (MHC) were divergently selected for either progression or regression of tumors induced at
4 weeks of age by a SR-D strain of Rous sarcoma virus (RSV). The first generation of selection was based on a progeny test
and subsequent selections were performed on full-sibs. Data of 18 generations including a total of 2010 birds measured were
analyzed for the tumor profile index (TPI), a synthetic criterion of resistance derived from recording the volume of the tumors
and mortality. Response to selection and heritability of TPI were estimated using a restricted maximum likelihood method with
an animal model. Significant progress was shown in both directions: the lines differing significantly for TPI and mortality
becoming null in the "regressor" line. Heritability of TPI was estimated as 0.49 ± 0.05 and 0.53 ± 0.06 within the progressor
and regressor lines respectively, and 0.46 ± 0.03 when estimated over lines. Preliminary results showed within the progressor
line a possible association between one Rfp-Y type and the growth of tumors.

chicken-selection-resistance-Rous sarcoma-
Rfp - Y

  • Pediatrics 11/1948; 2(4):469-79. · 5.30 Impact Factor
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    ABSTRACT: The fate of tumors induced by Rous sarcoma virus (RSV) was determined in anF2 population segregating at three alloantigen loci. TheF1 resulted from crossing tumor-resistant RPRL line 61 (B2B2D3D3I2I2) with tumor-susceptible RPRL line 151 (B5B5D4D4I8I8). Among theF2 segregantsB2B2,B2B5, andB5B5, the percentage of chicks dying of terminal tumors (by 70 days post-inoculation) was 5, 26, and 93, respectively (P?0.01). NeitherD orI genotypes nor sex significantly affected tumor growth. In chickens with terminal tumors, the incidence of metastatic lesions was also significantly associated withB genotypes. Thus, the MHC chromosomal region in the chicken appears to exert a crucial role in determining the outcome of RSV-induced tumors.
    Immunogenetics 12/1977; 5(1):333-343. DOI:10.1007/BF01570490 · 2.49 Impact Factor
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    ABSTRACT: The resolution of genes that determine resistance to disease is described using chicken lines maintained at the Avian Disease and Oncology Laboratory (ADOL). This description includes a summary 1) of existing selected and inbred lines differing for resistance to viral-induced tumors, i.e., Marek's disease (MD) and lymphoid leukosis (LL), and of the use of inbred and line crosses to define relevant disease-resistant genes, e.g., TV, ALVE, B, R, LY4, TH1, BU1, and IGG1; 2) of the development of TVB*/ALVE congenic lines to establish the affects of endogenous virus (EV) expression on resistance to avian leukosis virus (ALV), and methods to detect ALVE expression; 3) of the development of B congenic lines to define the influence of the MHC on MD resistance and vaccinal immunity, for producing B antisera, and for evaluating DNA sequences of Class I and II genes; and 4) of the current development of 6C.7 recombinant congenic strains (RCS) to define the role of non-MHC genes influencing susceptibility to MD and LL tumors, immune competence, and epistatic effects of genes. The procedures of pedigree mating, to avoid or maintain inbreeding, and of blood-typing, to ensure genetic purity of the lines, are also described.
    Poultry Science 09/2000; 79(8):1082-93. DOI:10.1093/ps/79.8.1082 · 1.54 Impact Factor

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