Shear stress effects on plant cell suspension cultures in a rotating wall vessel bioreactor

Journal of Industrial Microbiology and Biotechnology (Impact Factor: 2.51). 12/1998; 22(1):44-47. DOI: 10.1038/sj.jim.2900600

ABSTRACT A rotating wall vessel, designed for growth of mammalian cells under microgravity, was used to study shear effects on Taxus cuspidata plant suspension cell cultures. Shear stress, as quantified by defined shear fields of Couette viscometers, improved specific
cell growth rates and was detrimental to volumetric product formation rates.

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