Application of advances in molecular biology to the treatment of brain tumors

Current Oncology Reports (Impact Factor: 2.87). 04/2012; 2(5):425-433. DOI: 10.1007/s11912-000-0062-4

ABSTRACT Recent advances in molecular biology have substantially improved our understanding of the molecular genetics of primary brain
neoplasms. Soon each histopathologic category of glioma will be further divided into subgroups according to similar genetic
background, gene expression profile, and similarity of biologic responses to radiotherapy or chemotherapy. Identification
of key molecules that are specifically altered in neoplastic cells will provide candidate molecular targets for tumor treatment.
Novel therapeutic tools for targeting tumor cells, such as viral vectors for gene therapy, have been created. In the near
future, the accumulation of new knowledge in brain tumor biology and genetics, combined with rational drug design, will revolutionize
the treatment of malignant gliomas, which are among the most lethal human cancers.

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