Article

The Role of Circadian Rhythm in the Pathogenesis of Colorectal Cancer

Department of Oncology/Hematology, WJB Dorn Veterans Affairs Medical Center, University of South Carolina School of Medicine, 6439 Garners Ferry Road, Columbia, SC 29209, USA; Department of Pathology, Immunology and Microbiology, University of South Carolina School of Medicine, 6439 Garners Ferry Road, Columbia, SC 29209, USA; Department of Epidemiology and Biostatistics, University of South Carolina, 6439 Garners Ferry Road, Columbia, SC 29209, USA; Department of Computer Science and Engineering, University of South Carolina, 6439 Garners Ferry Road, Columbia, SC 29209, USA
Current Colorectal Cancer Reports 04/2012; 6(2):74-82. DOI:10.1007/s11888-010-0045-2 pp.74-82

ABSTRACT The circadian clock controls many cellular processes, some of which are key to tumor suppression, including cell proliferation
and apoptosis, DNA repair, metabolism, hormone signaling, and immune function. The association between altered circadian clock
function and increased risk of colorectal cancer is increasingly evident from epidemiologic, preclinical, and clinical studies.
In this review, we discuss several distinct mechanisms by which altered components of the circadian clock might promote intestinal
tumorigenesis. We also review the progress in identifying circadian and clock-based molecular processes that might be targeted
to promote the prevention and control of colorectal cancer.

KeywordsCircadian clock-Colorectal cancer-Period-Melatonin

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Keywords

cell proliferation
 
cellular processes
 
circadian clock
 
circadian clock controls
 
clock-based molecular processes
 
colorectal cancer
 
distinct mechanisms
 
hormone signaling
 
KeywordsCircadian clock-Colorectal cancer-Period-Melatonin
 
preclinical
 
tumor suppression
 

Patricia A Wood