Polyamines in Pulmonary Vascular Biology

DOI: 10.1007/978-1-59745-145-1_11


Polyamines are essential for cell growth and development. They regulate many functions, including cell division, migration,
ion channel regulation, apoptosis, and the cellular synthesis of DNA, RNA, and proteins. A recent review on the roles of polyamines
in the lung emphasized studies on respiratory cell biology and polyamine uptake (1). The primary goal of this chapter is to review evidence that polyamines contribute to phenotypical changes in pulmonary vascular
cells that underlie the pathogenesis of pulmonary arterial hypertension. Because arginases can regulate polyamines, their
potential role in the pathogenesis of pulmonary hypertension and asthma also will be reviewed. The data suggest polyamines
may be future therapeutic targets for pulmonary hypertension, although clinical trials measuring polyamines and their regulation
are lacking.

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