Chapter

TH17 Cells in Organ Transplantation Rejection and Tolerance

12/2010; DOI:10.1007/978-1-4419-9371-7_17

ABSTRACT The emergence of TH17 cells as a distinct subset of effector T cell has led to a revised model of the adaptive immune system. In experimental
and clinical transplantation, the TH17-producing cytokine, interleukin (IL)-17, is evident in allograft rejection. It is conceivable that TH17 cells could play a specific role in pathogenic process of allograft rejection. This chapter summarizes the current spectrum
of TH17 cells in transplant rejection. The tolerance and regulation of TH17 response in the allogeneic context is also discussed.

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Keywords

adaptive immune system
 
clinical transplantation
 
current spectrum
 
distinct subset
 
effector T cell
 
evident
 
pathogenic process
 
revised model
 
specific role
 
TH17 cells
 
TH17 response
 
TH17-producing cytokine
 

Julia Tsang