TH17 Cells in Organ Transplantation Rejection and Tolerance

DOI: 10.1007/978-1-4419-9371-7_17 In book: TH17 Cells in Health and Disease, pp.319-339


The emergence of TH17 cells as a distinct subset of effector T cell has led to a revised model of the adaptive immune system. In experimental
and clinical transplantation, the TH17-producing cytokine, interleukin (IL)-17, is evident in allograft rejection. It is conceivable that TH17 cells could play a specific role in pathogenic process of allograft rejection. This chapter summarizes the current spectrum
of TH17 cells in transplant rejection. The tolerance and regulation of TH17 response in the allogeneic context is also discussed.

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