Article

Simultaneous occurrence of the haemolytic uraemic syndrome and acute post-infectious glomerulonephritis

European Journal of Pediatrics (impact factor: 1.88). 01/2001; 160(3):173-176. DOI:10.1007/s004310000684 pp.173-176

ABSTRACT We report on two children, a 12-year-old boy and a 6-year-old girl, with simultaneous occurrence of clinical and laboratory
features consistent with both diarrhoea-negative haemolytic uraemic syndrome (D-HUS) and acute post-infectious glomerulonephritis
(APGN). Both presented with acute renal insufficiency, hypertension and oedema. Laboratory evaluation revealed micro-angiopathic
anaemia with burr cells, thrombocytopenia, elevated lactic dehydrogenase and low complement C3. Urinalysis showed marked proteinuria
and haematuria. Renal biopsy was characteristic of APGN, but not of HUS. The outcome was good in both children.

Conclusion The simultaneous occurrence of diarrhoea-negative haemolytic uraemic syndrome and acute post-infectious glomerulonephritis
is rare. The outcome is generally good as is expected in the latter condition in contrast to the former.

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Keywords

12-year-old boy
 
6-year-old girl
 
acute post-infectious glomerulonephritis
 
acute renal insufficiency
 
APGN
 
burr cells
 
children
 
diarrhoea-negative haemolytic uraemic syndrome
 
former
 
haematuria
 
Laboratory evaluation
 
lactic dehydrogenase
 
simultaneous occurrence
 
thrombocytopenia
 
Urinalysis
 

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