Simultaneous occurrence of the haemolytic uraemic syndrome and acute post-infectious glomerulonephritis
ABSTRACT We report on two children, a 12-year-old boy and a 6-year-old girl, with simultaneous occurrence of clinical and laboratory
features consistent with both diarrhoea-negative haemolytic uraemic syndrome (D-HUS) and acute post-infectious glomerulonephritis
(APGN). Both presented with acute renal insufficiency, hypertension and oedema. Laboratory evaluation revealed micro-angiopathic
anaemia with burr cells, thrombocytopenia, elevated lactic dehydrogenase and low complement C3. Urinalysis showed marked proteinuria
and haematuria. Renal biopsy was characteristic of APGN, but not of HUS. The outcome was good in both children.
Conclusion The simultaneous occurrence of diarrhoea-negative haemolytic uraemic syndrome and acute post-infectious glomerulonephritis
is rare. The outcome is generally good as is expected in the latter condition in contrast to the former.