Frontotemporal dementia with ubiquitinated cytoplasmic and intranuclear inclusions
ABSTRACT Dementia of motor neuron disease type (DMND) is a variety of frontotemporal dementia (FTD) which is pathologically defined by characteristic neuronal ubiquitinated, tau- and synuclein-negative intracytoplasmic inclusions. Many cases with this pathology, however, do not have motor neuron disease. In the present study, we document the presence of ubiquitinated neuronal intranuclear inclusions in a sub-population of cases of neuropathologically verified DMND. Immunohistochemical localization of ubiquitin was performed on sections of post-mortem brain from 12 patients with DMND as well as from cases with other neurodegenerative diseases including amyotrophic lateral sclerosis, Parkinson's disease, dementia with Lewy bodies, corticobasal degeneration, progressive supranuclear palsy, and multiple system atrophy. All of the cases of DMND showed ubiquitinated, tau-negative intracytoplasmic inclusions in dentate granule cells and cortical neurons. Of these 12 cases of DMND, 3 also showed neuronal ubiquitinated intranuclear inclusions. In 1 of these cases, CAG repeat expansions in the genes known to harbor these mutations were excluded. Cases with intranuclear inclusions displayed striatal atrophy and reduced brain weight relative to non-inclusion-bearing cases. In addition, patients with intranuclear inclusions tended to have a younger age of onset, a prolonged duration of disease, absence of motor neuron symptoms, and a family history of dementia. Intranuclear inclusions were not identified in the control cases with other neurodegenerative diseases. Ubiquitinated neuronal intranuclear inclusions have not been reported previously in DMND. The presence of ubiquitinated intranuclear inclusions along with striatal atrophy in a subset of cases of DMND may signify the existence of a neuropathologically distinct subset of this unique form of FTD.
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ABSTRACT: The dynamics of a composite system containing two orthogonal degenerate whispering-gallery cavity modes coupling to a quantum dot (QD) is presented by a full quantum approach. The energy levels of the quantum dot are modeled as a V-type three-level system, which consist of the ground state, right- and left-polarized excitons. The counterclockwise mode a and the clockwise mode b are coupled with the transitions corresponding to the right- and left-polarized excitons with coupling rates gR and gL, respectively. An exact solution is proposed in a real-space approach. We majorly discuss the effects of the backscattering rate β on the spectra of the transmission and reflection in a strong coupling regime. A new insight is that one can overcome the excitons' fine structure splitting of a real QD with appropriate backscattering rate β by fine designing the cavity, which would be possible for applications to produce the degenerate entangled photon pairs in a real QD system.Optics Communications 06/2011; 284(12):2937-2942. DOI:10.1016/j.optcom.2011.02.024 · 1.54 Impact Factor