Article

Kinetics and mechanism of electron-induced splitting of a cyclobutane pyrimidine dimer with or without an electron acceptor

Science in China Series B Chemistry (impact factor: 1.2). 04/2012; 46(5):439-444. DOI:10.1360/03yb0038 pp.439-444

ABSTRACT Utilizing a pulse radiolysis equipment with time-resolved optical detector, kinetic processes of electron-induced splitting
of cis-syn 1,3-dimethyluracil cyclobutane dimer (DMUD) in aqueous solution were investigated in the presence or absence of riboflavin
(RF) or flavin adenine dinucleotide (FAD). It has been observed that the cyclobutane pyrimidine dimer reacting with hydrated
electron splits spontaneously to give a monomer and a monomer radical anion, and the anion transfers one electron to RF or
FAD. From the buildup kinetics of radical species, the rate constants of electron transfer from the monomer radical anion
to RF and FAD have been determined. On the basis of comparison of the interactions between DMUD and hydrated electron in the
presence and absence of RF or FAD, a chain reaction process in the absence of RF or FAD has been demonstrated.

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Keywords

anion transfers
 
aqueous solution
 
buildup kinetics
 
chain reaction process
 
cis-syn 1,3-dimethyluracil cyclobutane dimer
 
cyclobutane pyrimidine dimer
 
electron-induced splitting
 
FAD
 
flavin adenine dinucleotide
 
hydrated electron
 
interactions
 
kinetic processes
 
monomer radical anion
 
pulse radiolysis equipment
 
radical species
 
rate constants
 
RF
 
time-resolved optical detector
 

Liqin Yan