Fabrication and Characterization of Porous Calcium Polyphosphate Scaffolds

Department of Polymer Science, Sichuan University, Hua-yang, Sichuan, China
Journal of Materials Science (Impact Factor: 2.37). 04/2006; 41(8):2429-2434. DOI: 10.1007/s10853-006-5182-2


Porous calcium polyphosphate (CPP) scaffolds with different polymerization degree and crystalline phases were prepared, and
then analyzed by scanning electron microscopy (SEM), Thermmogravimetry (TG) and X-ray diffraction (XRD). Number average polymerization
degree was calculated by analyzing the calcining process of raw material Ca(H2PO4)2, as a polycondensation reaction. Amorphous CPP were prepared by the quenching from the melt of Ca(H2PO4)2 after calcining, and CPP with different polymerization degree was prepared by controlling the calcining time. Meanwhile,
CPP with the same polymerization degree was prepared to amorphous or different crystalline phases CPP which was made from
crystallization of amorphous CPP. In vitro degradation studies using 0.1 M of tris-buffered solution were performed to assess the effect of polymerization degree or
crystalline phases on mechanical properties and weight loss of the samples. With the increase of polymerization degree, the
weight loss during the degradation decreased, contrarily the strength of CPP increased. The degradation velocity of amorphous
CPP, α-CPP, β-CPP and γ-CPP with the same polymerization degree decreased in turn at the same period. The full weight loss
period of CPP can be controlled between 17 days and more than 1 year. The results of this study suggest that CPP ceramics
have potential applications for bone tissue engineering.

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    ABSTRACT: Preparation, characterization and in vitro study of a series of calcium polyphosphate (CPP) with different polymerization degree were reported. A series of CPP with different polymerization degree were prepared by controlling calcining time. Average polymerization degree was analyzed by liquid state 31P nuclear magnetic resonance (NMR). The microstructure was observed by scanning electric microscope (SEM). X-ray diffraction (XRD) analysis was used to demonstrate that polymerization degree would not affect the crystal system and space group of CPP. The results showed that polymerization degree increased with the increase of calcining time. Degradation studies were performed during 32 days in physiological saline solution (aqueous solution, 0.9 wt.%NaCl) to assess the effect of polymerization degree on the degradation velocity of the samples. It was also shown that the degradation velocity of CPP (polymerization degree=13) doubles than another two samples (polymerization degree=9,19). The results in the present study may be able to provide some fundamental data for controlling CPP degradation.
    Journal of Materials Science Materials in Medicine 04/2008; 19(3):1291-5. DOI:10.1007/s10856-007-3235-y · 2.59 Impact Factor
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    ABSTRACT: In this work, the degradation kinetics of calcium polyphosphate bioceramic was studied. Liquid state 31Pnuclear magnetic resonance (NMR), X-ray diffraction (XRD) and scanning electron microscope (SEM) were used to characterize the product. The in vitro degradation test was carried out at 37 ºC for up to 48 hours for both the simulation solution and the extreme solution. The ion concentrations were measured and analyzed by establishing a mathematical model referring to the chemical reaction kinetics. The results indicated that the degradability of calcium polyphosphate increased with the decrease of pH value, and the sample showed a rapid loss of ion concentration within the initial period of immersion followed by a slower loss ratio. The relationship between ion concentration and the degradation time coincided with Boxlucas model.
    Materials Research 12/2008; 12(4):495-501. DOI:10.1590/S1516-14392009000400020 · 0.79 Impact Factor
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