Mesenchymal Stem/Stromal Cells as Cellular Vehicles for Tumor Targeting
ABSTRACT Data published over the last 10 years suggest that mesenchymal stem/stromal cells (MSC) possess the innate capacity to home
to sites of inflammation, including tumors and wounding microenvironments. Evidence suggests that the increased production
of inflammatory mediators found at these sites is potential attractants for recruitment and engraftment. This innate homing
response can be exploited by using MSC as a cellular delivery vehicle to deliver anticancer agents directly to tumors. The
high-level intratumoral production of these agents controls tumor growth and prolongs survival in numerous animal models.
In this review, we examine the ability of MSC to selectively home to and engraft within the tumor microenvironment and the
multiple gene products delivered by MSC when used as delivery vehicles for anticancer therapies.
KeywordsCarcinoma-Associated Fibroblast (CAF)-Tumor Microenvironment-Tumor homing-Tumor stroma-Interferon-beta