Effect of microelements on the biosynthesis of secondary metabolites by the fungusPenicillium citrinum thom VKM F-1079
ABSTRACT Penicillium citrinum VKM F-1079 was found to produce clavine ergot alkaloids and citrinin, a secondaryO-heterocyclic metabolite. Citrinin was produced in the idiophase, whereas the production of ergot alkaloids paralleled fungal
growth. The addition of manganese ions to the growth medium stimulated the biosynthesis of both citrinin and ergot alkaloids.
Zinc ions stimulated only citrinin synthesis. The presence of these microelements in the growth medium influenced the proportion
between the ergot alkaloids synthesized. Copper, manganese, and iron ions slightly affected fungal growth and alkaloid production.
The effect of microelements on the main kinetic parameters of growth and alkaloid production was studied.