A comparison of the costs and effects of liver transplantation for acute and for chronic liver failure

Transplant International (Impact Factor: 2.6). 03/2001; 14(2):87-94. DOI: 10.1007/s001470050852


Little is known about costs and cost-effectiveness of liver transplantation (LTx) for acute liver failure compared to costs
and cost-effectiveness of LTx for chronic liver failure. In this study, costs of acute and of chronic LTx patients were determined
in a retrospective study. Files of 100 consecutive patients who underwent LTx in 1993–1997 were studied. Costs up to 1 year
after LTx were Euro 107,675 (chronic liver failure) and Euro 90,792 (acute liver failure). The difference was mainly caused
by higher hospitalisation costs and higher personnel costs for chronic liver failure. Medication costs for acute liver failure
were higher, due to a high administration rate of expensive anti-HBs immunoglobulin therapy in patients with viral hepatitis
B. LTx for chronic liver failure is more costly and seems to be more cost-effective than LTx for acute liver failure, since
1-year survival is higher in patients who underwent transplantation for chronic liver failure.

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