Article

High-yield production of short chain length poly(ε-l-lysine) consisting of 5–20 residues by Streptomycesaureofaciens, and its antimicrobial activity

MEA Laboratory, 4-31-18, Takakuradai, Sakai, 590-0117 Japan
Biotechnology Letters (impact factor: 1.68). 04/2012; 32(9):1299-1303. DOI:10.1007/s10529-010-0294-9

ABSTRACT Poly(ε-l-lysine) (ε-PL) is a naturally-occurring l-lysine homopolymer having antimicrobial activity. A newly-isolated strain of Streptomyces aureofaciens produced a short chain length ε-PL consisting of 5–20 residues at the highest production level of 4.5gl–1. This ε-PL had different spectra in terms of antimicrobial activity from the ε-PL that is now used as a food preservative.
The high productivity was based on multiple metabolic pathways for l-lysine synthesis, and a great flux from l-lysine to ε-PL. The usefulness of this new ε-PL and its producing strain was discussed.

KeywordsAntimicrobial activity-Metabolic pathways-Chain length-Poly(ε-l-lysine)-
Streptomyces

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Keywords

food preservative
 
highest production level
 
l-lysine synthesis
 
multiple metabolic pathways
 
new ε-PL
 
newly-isolated strain
 
Poly(ε-l-lysine)
 
producing strain
 
short chain length ε-PL
 
ε-PL
 

Munenori Takehara