High-yield production of short chain length poly(ε-l-lysine) consisting of 5–20 residues by Streptomycesaureofaciens, and its antimicrobial activity
ABSTRACT Poly(ε-l-lysine) (ε-PL) is a naturally-occurring l-lysine homopolymer having antimicrobial activity. A newly-isolated strain of Streptomyces aureofaciens produced a short chain length ε-PL consisting of 5–20 residues at the highest production level of 4.5gl–1. This ε-PL had different spectra in terms of antimicrobial activity from the ε-PL that is now used as a food preservative.
The high productivity was based on multiple metabolic pathways for l-lysine synthesis, and a great flux from l-lysine to ε-PL. The usefulness of this new ε-PL and its producing strain was discussed.
KeywordsAntimicrobial activity-Metabolic pathways-Chain length-Poly(ε-l-lysine)-
Article: The generation of hydrophilic polypeptide-siloxane conjugates via n-carboxyanhydride polymerisation[show abstract] [hide abstract]
ABSTRACT: A novel methodology to create covalently linked polypeptide-siloxane hybrid materials by controlled n-car-boxyanhydride ring opening polymerisation is disclosed. Poly-L-glutamic acid and poly-L-lysine conjugated products were formed that possessed excellent surface wettability. In addition, the poly-L-lysine-siloxane hybrids formed demonstrated bactericidal attributes against gram-positive Staphylococcus aureus and gram-negative Escherichia coli. It is anticipated that these materials may be of significance for the generation of hydrophilic siloxane-containing poly-mers that are commonly employed in contemporary medical devices.Journal of Materials Science Materials in Medicine 01/2011; · 2.32 Impact Factor