Chapter

Development and Structure of Lymph Nodes in Humans and Mice

12/2010; DOI:10.1007/978-3-642-14429-5_7

ABSTRACT Throughout the human body, 500–600 lymph nodes are situated. These secondary lymphoid organs collect antigens from peripheral
tissues via the afferent lymphatics and provide T and B lymphocytes with the optimal environment for cellular activation and
proliferation. In this chapter, we will highlight the interactions between hematopoietic cells and stromal cells that are
essential for the proper formation and organization of the lymph node. In addition, the distinct cellular architecture that
is characteristic for secondary lymphoid organs as well as its vascular system will be discussed in the context of lymph node
function.

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Keywords

B lymphocytes
 
cellular activation
 
hematopoietic cells
 
human body
 
interactions
 
lymph node
 
proper formation
 
secondary lymphoid organs
 
stromal cells
 
vascular system