Mixed ligand complexes with 2-piperidine-carboxylic acid as primary ligand and ethylene diamine, 2,2′-bipyridyl, 1,10-phenanthroline and 2(2′-pyridyl)quinoxaline as secondary ligands: Preparation, characterization and biological activity

Transition Metal Chemistry (Impact Factor: 1.31). 09/2007; 32(6):769-775. DOI: 10.1007/s11243-007-0247-x


Synthesis procedures are described for the new stable mixed ligand complexes, [Pd(Hpa)(pa)]Cl, [Pd(pa)(H2O)2]Cl, [Pd(pa)(en)]Cl, [Pd(pa)(bpy)]Cl, [Pd(pa)(phen)Cl], [Pd(pa)(pyq)Cl], cis-[MoO2(pa)2], [Ag(pa)(bpy)], [Ag(pa)(pyq)], trans-[UO2(pa)(pyq)](BPh4) and [ReO(PPh3)(pa)2]Cl (Hpa = 2-piperidine-carboxylic acid, en = ethylene diamine, bpy = 2,2′-bipyridyl, phen = 1,10-phenanthroline, pyq = 2(2′-pyridyl)quinoxaline).
Their elemental analyses, conductance, thermal measurements, Raman, IR, electronic, 1H-n.m.r. and mass spectra have been measured and discussed. 2-Piperidine-carboxylic acid and its palladium complexes have
been tested as growth inhibitors against Ehrlich ascites tumour cells (EAC) in Swiss albino mice.

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Available from: Sahar I. Mostafa, Feb 14, 2014
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    • "We have previously studied the chemotherapeutic potential of a series of Mo(VI), Pd(II), Pt(II), and Ag(I) complexes with N,O; N,S and O,O-donors. These complexes were found to display significant anticancer activity against Ehrlich ascites tumor cell (EAC) in albino mice [9] [10] [11] [12]. Copper(II) complexes of 6-methylpyridine- 2-carbaldehyde and its N(4)-methyl, ethyl, and phenyl thiosemicarbazones have been reported as well as their activity against pathogenic fungi [13]. "
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    ABSTRACT: New complexes of dioxovanadium(V), zinc(II), ruthenium(II), palladium(II), and platinum(II) with 6-methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone (HmpETSC) have been synthesized. The composition of these complexes is discussed on the basis of elemental analyses, IR, Raman, NMR ((1)H, (13)C, and (31)P), and electronic spectral data. The X-ray crystal structures of [VO(2)(mpETSC)] and [Pt(mpETSC)Cl] are also reported. The HmpETSC and its [Zn(HmpETSC)Cl(2)] and [Pd(mpETSC)Cl] complexes exhibit antineoplastic activity against colon cancer human cell lines (HCT 116).
    Bioinorganic Chemistry and Applications 07/2010; 2010(2):149149. DOI:10.1155/2010/149149 · 1.66 Impact Factor
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    • "Over the past years, a renewed interest in Pd(II) complexes as potential anticancer agents has developed. Though a number of interesting Pd(II) targets have been investigated [4] [5] [6] [7], the biological utility of such agents continues to be questioned, this may be due to the poor solubility of common Pd(II) complexes under physiologic conditions. Many studies, including nucleic and amino acid derivatives, showed that 2-mercaptopyrimidine and 2- mercapto-4-aminopyrimidine are able to inhibit the synthesis of t-RNA [8]. "
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    ABSTRACT: Synthesis of two new water-soluble mixed ligand [Pd(bpy)(dahmp)]Cl and [Ag(bpy)(Hdahmp)]NO(3) complexes (dahmp and Hdahmp are the deprotonated monoanion and the protonated neutral 4,6-diamino-5-hydroxy-2-mercaptopyrimidine, resp.) is reported. The composition of the reported complexes was discussed on the bases of IR, (1)H NMR, and mass spectra, as well as conductivity and thermal measurements. The reported complexes display a significant anticancer activity against Ehrlich ascites tumor cells (EACs). The higher activity of these complexes with their higher conductivity values corresponds to their complete ionization in aqueous solution.
    Metal-Based Drugs 02/2008; 2008. DOI:10.1155/2008/723634
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    ABSTRACT: New complexes of 2-thione-4,6-diamino-5-hydroxypyrimidine (HTDAHP) with Fe(III), Ni(II), Ag(I) and Ru (II) are described. IR, 1H-NMR and mass spectra, conductivity, magnetic and thermal measurements of the complexes are reported and their structures discussed. HTDAHP behaves as a bidentate ligand, forming five membered hydroxyl-amino chelates or four-membered cyclic nitrogen-sulphur chelates without any participation of the pendant amino or hydroxy groups in complexation. The biological activities of the Ag(I) complexes against fungi (Aspergillus niger and Candida albicans) and bacteria (Staphylococcus aureus and Pseudomonas aeruginosa) have been investigated.
    Transition Metal Chemistry 05/2008; 33(4):529-534. DOI:10.1007/s11243-008-9076-9 · 1.31 Impact Factor
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