Article

Duration of anti-cholecystokinin (CCK) action on the rat exocrine pancreas of new CCK receptor antagonist FK 480 administered orally

Journal of Gastroenterology (impact factor: 4.16). 02/1996; 31(2):249-253. DOI:10.1007/BF02389525

ABSTRACT We assessed the duration of the anti-cholecystokinin (CCK) action of FK480, a new non-peptide CCK-A receptor antagonist developed
in Japan, in an in vivo study in rats, comparing it with CR 1505. Pancreatic exocrine secretion stimulated by intravenous
infusion of CCK-8 (0.06 μg/kg per h) was measured at intervals of 0–24 h after the oral administration of FK480 (1.5 mg/kg)
and CR 1505 (30 mg/kg). FK480 significantly inhibited both CCK-stimulated pancreatic juice volume flow and amylase output
0, 4, 8, and 12h after oral administration, whereas the inhibitory effect of CR 1505 had completely disappeared by 8h after
oral administration. It was concluded that orally administered FK480 has a prolonged anti-CCK action.

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Keywords

CCK
 
CCK-8
 
CCK-stimulated pancreatic juice volume flow
 
Japan
 
new non-peptide CCK-A receptor antagonist
 
Pancreatic exocrine secretion
 
prolonged anti-CCK action
 

Yuriko Moriyoshi