Plasma lipid effects of corn oil and extra-virgin olive oil in hypercholesterolaemic subjects: a randomised, controlled trial

Mediterranean Journal of Nutrition and Metabolism 01/2009; 1(3):187-192. DOI: 10.1007/s12349-008-0028-x

ABSTRACT The aim of our study was to directly compare the metabolic effect of monounsaturated fatty acid rich oils and polyunsaturated
fatty acid rich oils on the plasma lipid pattern of moderately hypercholesterolaemic subjects under controlled isocaloric
condition. After a 30-day run-in diet, 44 healthy Caucasian subjects with moderate hypercholesterolaemia were randomly assigned
to one of four different isocaloric diets, differing only regarding the oil used (corn oil, corn oil supplemented with vitamin
E, extra-virgin olive oil or different self-selected oils), for 45 days. At the end of the study, when compared to the baseline
value, low-density lipoprotein (LDL)-cholesterolaemia was significantly lower only in patients taking corn oil (−13.9%; 95%CI
−5.9 to −20.1; p = 0.02) or corn oil with added vitamin E (−19.1%; 95%CI −6.9 to −24.1; p = 0.03). Differences in plasma high-density lipoprotein (HDL)-cholesterol and triglyceride levels from baseline levels and
between the four diets did not reach statistical significance.

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    ABSTRACT: Sesame oil could be considered as a potent antioxidant and dietary supplement. It possesses antimutagenic, anti-inflammatory and anti-cardiac toxicity. In the view of available findings, the current study focused on determining the protective effects of sesame oil on 4-Nitroquinoline-1-oxide (4-NQO) -induced oxidative DNA damage and lipid peroxidation (LPO) in rats. Seven groups of Wistar albino rats each with 6 either sex were used. Groups were given vehicle control and sesame oil alone orally and 4-NQO (30 mg/kg) by intraperitoneal injection. Following the four dose levels (1, 2, 4, and 8 ml/kg orally), sesame oil plus 4-NQO were also tested. After 24 hours of 4-NQO injection, blood samples were drawn by venipuncture. DNA damage (8-hydroxy-2-deoxy guanosine; 8-OHdG) and LPO were estimated. LPO from the 4-NQO-treated group was 2.5-fold higher than that of the control LPO. Pretreatment with sesame oil reduced this by 16-61%. 8-OHdG DNA damage from 4-NQO was found to be 3-fold higher than that of controls. Pretreatment with sesame oil effectively protected against DNA damage in a dose-dependent fashion. This study indicates that the antioxidant, sesame oil, effectively protected DNA damage and LPO induced by 4-NQO.
    Drug and Chemical Toxicology 04/2011; 34(2):116-9. · 1.10 Impact Factor