Article

Zur Transposition der Herzschlagadern. Ein kritischer Beitrag zur lehre der Transpositionen

Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin (Impact Factor: 2.68). 303(1):168-205. DOI: 10.1007/BF02595156
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    ABSTRACT: The formal genesis of transposition of the great arteries is treated in four parts: 1. Presentation of vectorial bulbus rotation on the basis of findings made on the human embryonal heart. 2. Interpretation of the different froms of transposition as disturbances of vectorial bulbus rotation. 3. Comments on other concepts relating to the morphogenesis of transposition: De la Cruz' theory of a straight bulbotruncal septum; Grant's interpretation of an abnormally developed heart skeleton; and Van Praagh's conal growth hypothesis recently advocated by Bankl and comparable to Keith's concept of an anomalous absorption of the bulbus. 4. Discussion of the main terminological problems of transposition. Vectorial bulbus rotation proves to be a correct interpretation of the more important stages in the development of the arterial end of the heart. The different forms of transposition can be easily explained on the basis of the pathogenic principle of an arrest of vectorial bulbus rotation. The conal growth hypothesis can be understood, in a causal sense, as an extension of the formal concept of vectorial bulbus rotation, but like the concepts of De la Cruz and Grant it is inadequately supported by the known facts of human cardiogenesis.
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