Article

Role of secretin and cholecystokinin in oleic acid-stimulated pancreatic secretion in rats

Tokyo Women’s Medical College Department of Gastroenterology 8-1 Kawada-cho, Shinjuku-ku 162 Tokyo Japan
Journal of Gastroenterology (impact factor: 4.16). 04/1990; 25(1):104-111. DOI:10.1007/BF02785336 pp.104-111

ABSTRACT We investigated the possible role of endogenous secretin and cholecytokinin (CCK) on oleic acid-stimulated pancreatic exocrine
secretion in anesthetized rats. Intraduodenal infusion of oleic acid (pH 6.5) in three different doses (0.06, 0.25 and 1 mmole/hr)
resulted in dose-related increases in pancreatic juice volume, bicarbonate and amylase outputs (r=0.665, 0.736 and 0.517,
respectively) (P<0.001). Plasma secretin and CCK concentrations also elevated significantly in response to oleic acid, in
a dose-related manner (r=0.721 and 0.546, respectively) (P<0.001). There were statistically significant correlations between
plasma secretin concentrations and bicarbonate outputs, and between plasma CCK concentrations and amylase outputs in response
to oleic acid (P<0.01). Potent CCK antagonist, CR 1409 (5 mg/kg.hr) administered intravenously suppressed completely increase
in amylase output induced by oleic acid, and partially in juice volume and bicarbonate output. It is concluded that both endogenous
secretin and CCK play important roles on oleic acid-induced pancreatic secretion in rats.

0 0
 · 
0 Bookmarks
 · 
15 Views
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

1 mmole/hr
 
amylase output induced
 
amylase outputs
 
anesthetized rats
 
bicarbonate
 
bicarbonate output
 
bicarbonate outputs
 
different doses
 
dose-related increases
 
dose-related manner
 
endogenous secretin
 
Intraduodenal infusion
 
intravenously suppressed
 
juice volume
 
pancreatic juice volume
 
plasma secretin concentrations
 
possible role
 
roles
 

Keiko Shiratori