Status of essential trace metals in biological samples of diabetic mother and their neonates

Archives of Gynecology and Obstetrics (Impact Factor: 1.33). 280(3):415-423. DOI:10.1007/s00404-009-0955-x

ABSTRACT ObjectiveThere is accumulating facts that the metabolism of essential trace elements is altered in diabetic patients. The aim of present
study was to compare the status of essential trace elements, chromium (Cr), manganese (Mn), and zinc (Zn) in biological samples
(whole blood, urine and scalp hair) of insulin dependent diabetic mothers (age ranged 30–40) and their newly born infants
(n=76). An age matched 68 non-diabetic mothers and their infants, residing in the same locality, were selected as referents.
For a comparative study, the biological samples of non-diabetic and diabetic pregnant and non pregnant of same age group and
socio-economics status were also analysed.

MethodologyThe biological samples (scalp hair, blood and urine) were collected from study and referent groups. The Cr, Mn and Zn concentrations
in all three biological samples were determined by a flame/electrothermal atomic absorption spectrometer, prior to microwave
assisted acid digestion. The validity and accuracy of the methodology was checked by certified reference materials (CRMs)
and using conventional wet acid digestion method on same CRMs.

ResultsThe mean values of Cr, Mn and Zn in scalp hair and blood samples of diabetic mothers and their infants were significantly
lower as compared to the referent mothers-infants pairs (p<0.01), while urinary excretion of all these elements were high in diabetic mother–infant pair samples.

ConclusionThe deficiencies of essential trace elements, Cr, Mn and Zn in biological samples of diabetic women, may play role in the
pathogenesis of diabetes mellitus and impacts on their neonates.

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