Status of essential trace metals in biological samples of diabetic mother and their neonates
ABSTRACT ObjectiveThere is accumulating facts that the metabolism of essential trace elements is altered in diabetic patients. The aim of present
study was to compare the status of essential trace elements, chromium (Cr), manganese (Mn), and zinc (Zn) in biological samples
(whole blood, urine and scalp hair) of insulin dependent diabetic mothers (age ranged 30–40) and their newly born infants
(n=76). An age matched 68 non-diabetic mothers and their infants, residing in the same locality, were selected as referents.
For a comparative study, the biological samples of non-diabetic and diabetic pregnant and non pregnant of same age group and
socio-economics status were also analysed.
MethodologyThe biological samples (scalp hair, blood and urine) were collected from study and referent groups. The Cr, Mn and Zn concentrations
in all three biological samples were determined by a flame/electrothermal atomic absorption spectrometer, prior to microwave
assisted acid digestion. The validity and accuracy of the methodology was checked by certified reference materials (CRMs)
and using conventional wet acid digestion method on same CRMs.
ResultsThe mean values of Cr, Mn and Zn in scalp hair and blood samples of diabetic mothers and their infants were significantly
lower as compared to the referent mothers-infants pairs (p<0.01), while urinary excretion of all these elements were high in diabetic mother–infant pair samples.
ConclusionThe deficiencies of essential trace elements, Cr, Mn and Zn in biological samples of diabetic women, may play role in the
pathogenesis of diabetes mellitus and impacts on their neonates.
- SourceAvailable from: Yonghua Li[Show abstract] [Hide abstract]
ABSTRACT: Trace element concentrations, as indicators of micronutrient status of healthy centenarians, have not been widely analyzed. This study aimed to assess trace element concentrations in the hair of healthy centenarians. The effects of gender and age on element concentrations were also investigated. Eleven trace elements (Al, Ba, Cd, Cr, Cu, Fe, Mo, Pb, Se, Sr and Zn) in the scalp hair of 107 healthy Chinese centenarians were examined. The overall reference values (RVs) in mg/kg for the hair concentrations of trace elements in centenarians were as follows: Al, 14.95; Ba, 2.68; Cd, 0.06; Cr, 0.59; Cu, 6.21); Fe, 19.37; Mo, 0.50; Pb, 4.64; Se, 0.37; Sr, 4.84; and Zn, 154.37. Data analysis found that only Cu and Zn concentrations show a normal distribution, and there is no significant difference between males and females in any element except Zn. However, the levels of Al, Cd, Cr, Fe, Mo, Pb decrease and the levels of Ba, Cu, Se, Sr, Zn increase with age in the centenarian cohort. Results also revealed that sufficient Zn and Se concentrations as well as low exposure to heavy metals pollution contribute to the longevity of centenarians. The results imply the possibility of manipulating trace element concentrations, especially Zn and Se concentrations in tissues, as a means for therapeutic modality in geriatric disease.Science of The Total Environment 03/2011; 409(8):1385-90. DOI:10.1016/j.scitotenv.2011.01.017 · 3.16 Impact Factor
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ABSTRACT: It is well established that both, the deficiency and possible overload of mineral micronutrients have adverse health effects. It is also generally accepted that non-essential xenobiotics contribute to oxidative damage, which is considered one of the principal factors in diabetes and its complications. The purpose of this work was to gain an insight on the global role of metal/metalloids in the progress of diabetes mellitus type 2. In such approach, aluminum, vanadium, chromium, manganese, cobalt, nickel, copper, zinc, arsenic, selenium, molybdenum, mercury, cadmium and lead were determined by inductively coupled plasma-mass spectrometry (ICP-MS) in serum and urine of 76 diabetic patients (age 52 ± 8 years, 5-16 years of DM2, 52 subjects with slight-to-moderate complications and 24 with severe complications). A series of anthropometric and clinical parameters usually evaluated in the follow-up of patients were assessed by standard methods. Statistical analysis (unpaired t-test, analysis of correlation and principal component analysis) was then carried out in search of possible relationships existing among metals/metalloids and these parameters. The results obtained suggest that antagonistic interaction between molybdenum and copper might be involved in the progress of diabetes complications.Diabetes research and clinical practice 03/2011; 91(3):333-41. DOI:10.1016/j.diabres.2010.12.014 · 2.54 Impact Factor
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ABSTRACT: A large body of evidence supports the concept that human pregnancy outcome is significantly influenced by the nutritional status of the mother. The consumption of "poor diets" has been associated with an increased risk for pregnancy complications, including gross structural birth defects, prematurity, low birth weight, and an increased risk for neurobehavioral and immunological abnormalities after birth. Forty-four years ago, zinc deficiency in mammals was shown to be teratogenic. Maternal zinc deficiency produces effects ranging from infertility and embryo/fetal death, to intrauterine growth retardation and teratogenesis. Postnatal complications of maternal zinc deficiency can also occur, and include behavioral abnormalities, impaired immunocompetence, and an elevated risk for high blood pressure in the offspring. It has been suggested that developmental zinc deficiency in humans can present a significant challenge to the conceptus, increasing the risk for numerous defects. Developmental zinc deficiency can occur through multiple pathways, and the concept that acute phase response-induced changes in maternal zinc metabolism may be a common cause of embryonic and fetal zinc deficiency is presented. Potential mechanisms underlying the teratogenic effects of zinc deficiency are reviewed. The potential value of maternal zinc supplementation in high risk pregnancies is discussed.Birth Defects Research Part B Developmental and Reproductive Toxicology 08/2010; 89(4):313-25. DOI:10.1002/bdrb.20264 · 1.17 Impact Factor