Status of essential trace metals in biological samples of diabetic mother and their neonates

Archives of Gynecology and Obstetrics (Impact Factor: 1.36). 09/2009; 280(3):415-423. DOI: 10.1007/s00404-009-0955-x


ObjectiveThere is accumulating facts that the metabolism of essential trace elements is altered in diabetic patients. The aim of present
study was to compare the status of essential trace elements, chromium (Cr), manganese (Mn), and zinc (Zn) in biological samples
(whole blood, urine and scalp hair) of insulin dependent diabetic mothers (age ranged 30–40) and their newly born infants
(n=76). An age matched 68 non-diabetic mothers and their infants, residing in the same locality, were selected as referents.
For a comparative study, the biological samples of non-diabetic and diabetic pregnant and non pregnant of same age group and
socio-economics status were also analysed.

MethodologyThe biological samples (scalp hair, blood and urine) were collected from study and referent groups. The Cr, Mn and Zn concentrations
in all three biological samples were determined by a flame/electrothermal atomic absorption spectrometer, prior to microwave
assisted acid digestion. The validity and accuracy of the methodology was checked by certified reference materials (CRMs)
and using conventional wet acid digestion method on same CRMs.

ResultsThe mean values of Cr, Mn and Zn in scalp hair and blood samples of diabetic mothers and their infants were significantly
lower as compared to the referent mothers-infants pairs (p<0.01), while urinary excretion of all these elements were high in diabetic mother–infant pair samples.

ConclusionThe deficiencies of essential trace elements, Cr, Mn and Zn in biological samples of diabetic women, may play role in the
pathogenesis of diabetes mellitus and impacts on their neonates.

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    • "The results reported in the above mentioned studies indicate higher serum concentration levels of copper, lead, arsenic, cadmium, nickel, aluminum, and lower levels of selenium, chromium, manganese, and zinc in diabetic patients than healthy individuals. Several micronutrients have beneficial effects in healthy individuals and also in diabetic patients [20]. In particular, copper, zinc, selenium, iron, or manganese are essential components of metal enzymes such as Se containing glutathione peroxidase, Cu/Fe cytochrome C oxidase, or different types of superoxide dismutases; all of them are important in intra- and extracellular antioxidant defense. "
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    ABSTRACT: In this paper, we studied the relation between the micronutrient and gestational diabetes. Therefore, we measured micronutrient concentration including Ni, Al, Cr, Mg, Fe, Zn, Cu, and Se in serum of women with gestational diabetes between 24 and 28 weeks of gestational age (study group) who had inclusion criteria and comparison with micronutrient levels in normal pregnant women with same gestational age (control group). Results showed that there was no significant difference between the serum micronutrient level (Ni, Al, Cr, Mg, Zn, Cu, Se) in study and control groups except serum level of iron which in serum of gestational diabetic women was lower than normal pregnant women and difference was significant.
    ISRN obstetrics and gynecology 09/2012; 2012(4):470419. DOI:10.5402/2012/470419
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    • "Many studies have documented that plasma zinc levels are lower in obese individuals [2,3]. Furthermore, zinc deficiency may predispose glucose intolerance and insulin resistance, diabetes mellitus, and coronary artery disease [4-6]. "
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    ABSTRACT: Zinc deficiency is known to be associated with insulin resistance in obese individuals. This study was performed to evaluate the effect of zinc supplementation on insulin resistance and metabolic risk factors in obese Korean women. Forty obese women (body mass index (BMI) ≥ 25 kg/m(2)) aged 19-28 years were recruited for this study. Twenty women of the study group took 30 mg/day of supplemental zinc as zinc gluconate for 8 weeks and 20 women of control group took placebo. Usual dietary zinc intake was estimated from 3-day diet records. Insulin resistances were measured using Homeostasis model assessment (HOMA) indices, and insulin sensitivities Matsuda indices, which were calculated using oral glucose tolerance test data. Metabolic risk factors, such as waist circumference, blood pressure, fasting glucose, triglyceride, high density lipoprotein (HDL) cholesterol, and adipocyte hormones such as leptin, and adiponectin were also measured. At the beginning of study, dietary zinc averaged 7.31 mg/day and serum zinc averaged 12.98 µmol/L in the study group. Zinc supplementation increased serum zinc by 15% and urinary zinc by 56% (P < 0.05). HOMA values tended to decrease and insulin sensitivity increased slightly in the study group, but not significantly so. BMI, waist circumference, blood pressure, blood glucose, triglyceride, HDL cholesterol, and adipocyte hormones did not change in either the study or control group. These results suggest that zinc status may not affect insulin resistance and metabolic risk factors in obese Korean women. Further research is required on a larger cohort with a longer follow-up to determine the effects of zinc status on insulin resistance and metabolic variables.
    Nutrition research and practice 06/2012; 6(3):221-5. DOI:10.4162/nrp.2012.6.3.221 · 1.44 Impact Factor
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    • "Body tissues have been widely used in the biomonitoring of heavy metals and organic pollutants in large cohorts (Violante et al., 2000; Morton et al., 2002; Wilhelm et al., 2002; Pereira et al., 2004; Rodrigues et al., 2008; Zhao et al., 2008; Wang et al., 2009). Determination of trace element concentrations and their distribution in body tissues have also proven useful in assessing the health and nutritional status of target populations (Sarmani, 1987; Perrone et al., 1996; Kolmogorov et al., 2000; Senofonte et al., 2000; Skalnaya and Demidov, 2007; Kandhro et al., 2008, 2009; Afridi et al., 2009). "
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    ABSTRACT: Trace element concentrations, as indicators of micronutrient status of healthy centenarians, have not been widely analyzed. This study aimed to assess trace element concentrations in the hair of healthy centenarians. The effects of gender and age on element concentrations were also investigated. Eleven trace elements (Al, Ba, Cd, Cr, Cu, Fe, Mo, Pb, Se, Sr and Zn) in the scalp hair of 107 healthy Chinese centenarians were examined. The overall reference values (RVs) in mg/kg for the hair concentrations of trace elements in centenarians were as follows: Al, 14.95; Ba, 2.68; Cd, 0.06; Cr, 0.59; Cu, 6.21); Fe, 19.37; Mo, 0.50; Pb, 4.64; Se, 0.37; Sr, 4.84; and Zn, 154.37. Data analysis found that only Cu and Zn concentrations show a normal distribution, and there is no significant difference between males and females in any element except Zn. However, the levels of Al, Cd, Cr, Fe, Mo, Pb decrease and the levels of Ba, Cu, Se, Sr, Zn increase with age in the centenarian cohort. Results also revealed that sufficient Zn and Se concentrations as well as low exposure to heavy metals pollution contribute to the longevity of centenarians. The results imply the possibility of manipulating trace element concentrations, especially Zn and Se concentrations in tissues, as a means for therapeutic modality in geriatric disease.
    Science of The Total Environment 03/2011; 409(8):1385-90. DOI:10.1016/j.scitotenv.2011.01.017 · 4.10 Impact Factor
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