Article

The study on the relationship between serum vascular endothelial growth factor and proteinuria in adriamycin-induced nephrotic rats

Journal of Huazhong University of Science and Technology (impact factor: 0.38). 04/2012; 21(4):301-303. DOI:10.1007/BF02886562 pp.301-303

ABSTRACT To study the relationship between serum vascular endothelial growth factor (VEGF) and proteinuria in adriamycin-induced nephrotic
rats, a rat model of adriamycin-induced nephrotitis was developed by injection of adriamycin into a tail vein in a rat. At
different time points, 24-h urinary protein excretion was measured by using Coomassie brilliant blue method and the serum
VEGF levels detected by using ELISA assay. The interventional effect of VEGF on this model was observed. The results showed
that: (1) The adriamycin-induced nephrotic syndrome rat model was developed successfully; (2) Serum VEGF levels and proteinuria
were significantly increased at 7th day after intravenous injection of adriamycin. There was a positive correlation between
serum VEGF levels and 24-h urinary protein excretion (r=0. 67,P<0. 05). (3) The 24-h urinary protein excretion was significantly increased in the rats receiving administration of VEGF (P<0. 05). It was concluded that VEGF might play an important role in the pathogenesis of proteinuria in adriamycin-induced
nephrotic rats.

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Keywords

24-h urinary protein excretion
 
7th day
 
adriamycin-induced nephrotic syndrome rat model
 
adriamycin-induced nephrotitis
 
Coomassie brilliant blue method
 
different time points
 
ELISA assay
 
intravenous injection
 
pathogenesis
 
positive correlation
 
proteinuria
 
rat model
 
rats
 
serum vascular endothelial growth factor
 
serum VEGF levels
 
tail vein
 
VEGF
 

Zhu Zhonghua