Effect of supplementation with fortified olive oil on biochemical markers of bone turnover in healthy women

Mediterranean Journal of Nutrition and Metabolism 10/2008; 1(2):117-120. DOI: 10.1007/s12349-008-0015-2


Osteocalcin (OC) is a bone Gla protein synthesized by osteoblasts which have a high affinity for calcium. To adequately carboxylate
OC to form carboxylated OC (cOC), the osteoblasts require sufficient vitamin K. If vitamin K is deficient, under-carboxylated
OC (ucOC) is produced. The ratio between ucOC and cOC (UCR) as well as the levels of circulating ucOC are used as indicators
of the vitamin K status of bone. The aim of the present study was to compare the vitamin K status of bone by measuring the
plasma levels of ucOC and UCR in healthy adult women before and after 3 weeks of oral supplementation with 20 ml/day Petrini
Plus extra virgin olive oil. Petrini Plus is an organic olive oil enriched with vitamins D3, K1 and B6. Enrolled in the study were 15 healthy female volunteers (aged 25–40 years). Plasma levels of ucOC and cOC were measured
by ELISA. ucOC was found to be reduced and UCR was reduced by 44% after Petrini Plus olive oil supplementation. Petrini Plus
extra virgin olive oil might therefore be useful for bone protection as it was able to counteract bone loss in healthy volunteers.

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    ABSTRACT: Osteoporosis represents a serious health problem worldwide associated with an increased risk of fractures and mortality. Nutrition should form part of bone disease prevention strategies, especially in the light of the population ageing and the diet effect on bone health. Thus the study aimed at verifying whether 1 year of oral supplementation with either extra virgin olive oil (VOO) enriched with vitamins D3, K1 and B6 (VitVOO) or VOO used as placebo (PlaVOO) is able to modify some bone turnover and oxidative stress markers. Bone mineral density (BMD) was assessed in 60 healthy post-menopausal women together with the bone vitamin K status by measuring undercarboxylated osteocalcine (ucOC) plasma levels, the ratio between ucOC and carboxylated osteocalcine (UCR) and the relations with oxidative stress markers. After 1 year (T 1), subjects taking VitVOO showed lower ucOC levels than those taking PlaVOO; the same trend was found for UCR. As far as BMD is concerned, a significant increase in T-score at T 1 in VitVOO subjects compared to PlaVOO was found. All oxidative stress markers as thiobarbituric acid reactive substances, lipid hydroperoxides and conjugated dienes showed a significant reduction after VitVOO supplementation, whilst plasma total antioxidant capacity values was significantly increased in VitVOO group compared to PlaVOO group at T 1. It might be suggested that the use of VitVOO in the diet of post-menopausal women could represent a proper tool for bone protection and a useful strategy against oxidative stress and related diseases, thus confirming the antioxidant role played by the added vitamins.
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