Article

Norditerpenoid and dianthramide glucoside alkaloids from cultivatedaconitum species from Korea

Kyung Hee University Department of Oriental Pharmaceutical Sciences 130-701 Seoul Korea; Korea Research Institute of Bioscience and Biotechnology Daejon; School of Biotechnology, Yeungnam University Gyeongsan; Dongguk University Gyeongju Korea
Archives of Pharmacal Research (impact factor: 1.59). 04/2012; 30(6):691-694. DOI:10.1007/BF02977629

ABSTRACT A new norditerpene alkaloid named 8-O-methylhypaconine (1) was isolated along with twelve known alkaloids from the underground
parts of an unknown species ofAconitum plant culti-vated in Korea. Among the known alkaloids, two dianthramide glucosides, N-(2′-β-glucopyra-nosyl-5′-hydroxysalicyl)-5-hydroxyanthranilic
acid methyl ester (2) and N-(2′-β-glucopyranosyl-5′-hydroxysalicyl)-5-hydroxy-6-methoxyanthranilic acid methyl ester (3),
were isolated fromAconitum plants for the first time. The structures were established on the basis of chemical and spectroscopic methods.

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Keywords

acid methyl ester
 
dianthramide glucosides
 
known alkaloids
 
N-(2′-β-glucopyranosyl-5′-hydroxysalicyl)-5-hydroxy-6-methoxyanthranilic acid methyl ester
 
spectroscopic methods
 
unknown species ofAconitum plant culti-vated