Brief Report: No Evidence for Parvovirus B19 or Hepatitis E Virus as a Cause of Acute Liver Failure

Digestive Diseases and Sciences (Impact Factor: 2.55). 09/2006; 51(10):1712-1715. DOI: 10.1007/s10620-005-9061-5
Source: PubMed

ABSTRACT Viral hepatitis A and B are known to cause acute liver failure. While nearly 20% of acute liver failure cases are of indeterminate
etiology, screening for other viruses has not been uniformly performed. We looked for evidence for parvovirus B19 and hepatitis
E virus in sera from U.S. acute liver failure patients. For B19, 78 patients’ sera, including 34 with indeterminate etiology,
were evaluated by DNA dot-blot hybridization, reverse transcription polymerase chain reaction, and enzyme-linked immunosorbent
assay for immunoglobin G and M antibodies; none showed evidence for infection. In like manner, 126 patients’ sera were analyzed
for hepatitis E virus RNA by reverse transcription polymerase chain reaction and for hepatitis E virus immunoglobin G and
M antibodies by enzyme-linked immunosorbent assay; no acute hepatitis E virus cases were identified. If a unique acute liver
failure virus exists, it is neither of these candidate agents.

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