Biological importance of imidazole nucleus in the new millennium

Medicinal Chemistry Research (Impact Factor: 1.4). 11/2011; 20(8):1119-1140. DOI: 10.1007/s00044-010-9472-5


Imidazole nucleus is a constituent of many bioactive heterocyclic compounds that are of wide interest because of their diverse
biological and clinical applications. This created interest in researchers to synthesize variety of imidazole derivatives
and to screen them for their various biological activities viz. anti-cancer, anti-viral, antiHIV, anti-protozoal, anti-mycobacterial,
anti-inflammatory, analgesic, anxiolytic, as well anti-diabetic activities.

KeywordsImidazole–Anti-cancer–Analgesic–Anti-bacterial activity

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