Article

Plasmacytoid dendritic cells

Immunologic Research (impact factor: 3.03). 04/2012; 32(1):75-83. DOI:10.1385/IR:32:1-3:075 pp.75-83

ABSTRACT Plasmacytoid dendritic cells (pDCs) have been associated with several names and functions over time, reflecting the limited
availability of specific markers and their ability to produce large amounts of type I interferons, present antigens, as well
as prime disparate T-cell helper responses. Yet, there is increasing evidence that pDCs are a distinct cell type in the innate
immune system. This review high-lights aspects in which pDCs are unique in comparison to other antigen-presenting cells in
regulating innate and adaptive immune responses.

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Keywords

adaptive immune responses
 
antigen-presenting cells
 
distinct cell type
 
pDCs
 
Plasmacytoid dendritic cells
 
present antigens
 
prime disparate T-cell helper responses
 
regulating innate
 
review high-lights aspects
 

Winfried Barchet