Release of cationic drugs from loaded clay minerals

Nanostructured Materials Research Group of Hungarian Academy of Sciences, 6720 Szeged, Aradi vértanúk tere 1, Hungary HU
Colloid and Polymer Science (Impact Factor: 2.41). 11/2001; 279(12):1177-1182. DOI: 10.1007/s003960100527

ABSTRACT The adsorption of promethazine chloride [10-(2-dimethylammonium propyl) fenothiazine chloride] and buformin hydrochloride
(1-butylbiguanidine chloride) on montmorillonite was studied in previous work. The present article focuses on the desorption
of these molecules from their organocomplexes in a medium of artificial intestinal juice (pH 7.0 ± 0.1) at the temperature
of the human body (37 ± 0.5 °C). The desorption was investigated by kinetic studies, basal spacing measurements and Fourier
transform IR studies. Important quantitative differences were observed: buformin, which adsorbed in a monolayer coverage,
exhibited a very high desorption rate, whereas promethazine formed a pseudotrilayer arrangement and showed a lower dissolution

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