Release of cationic drugs from loaded clay minerals

University of Szeged, Algyő, Csongrád, Hungary
Colloid and Polymer Science (Impact Factor: 1.87). 11/2001; 279(12):1177-1182. DOI: 10.1007/s003960100527


The adsorption of promethazine chloride [10-(2-dimethylammonium propyl) fenothiazine chloride] and buformin hydrochloride
(1-butylbiguanidine chloride) on montmorillonite was studied in previous work. The present article focuses on the desorption
of these molecules from their organocomplexes in a medium of artificial intestinal juice (pH 7.0 ± 0.1) at the temperature
of the human body (37 ± 0.5 °C). The desorption was investigated by kinetic studies, basal spacing measurements and Fourier
transform IR studies. Important quantitative differences were observed: buformin, which adsorbed in a monolayer coverage,
exhibited a very high desorption rate, whereas promethazine formed a pseudotrilayer arrangement and showed a lower dissolution

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    ABSTRACT: Adsorption of Promethazine hydrochloride (PHCl) onto KSF Montmorillonite from aqueous solution has been investigated. Experiments were conducted at various pH values, ionic backgrounds and solution temperatures. The pseudo-second-order equation successfully predicted the adsorption among the tried kinetics models (pseudo-first-order, pseudo-second-order and intraparticle diffusion). Langmuir, Freundlich and DR adsorption models were used to describe equilibrium isotherms and the isotherm constants were obtained. The increase in solution temperature caused a decrease in the adsorption capacity values found from Freundlich and DR isotherm. The adsorption type can be explained by combined ion exchange and physisorption. Thermodynamic parameters of adsorption of Promethazine hydrochloride (PHCl) onto KSF were also evaluated. The surface morphologies of KSF and PHCl loaded KSF were examined using a scanning electron microscope (SEM). FTIR measurements of samples were also conducted.
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    ABSTRACT: An overview of nanoclays or organically modified layered silicates (organoclays) is presented with emphasis placed on the use of nanoclays as the reinforcement phase in polymer matrices for preparation of polymer/layered silicates nanocomposites, rheological modifier for paints, inks and greases, drug delivery vehicle for controlled release of therapeutic agents, and nanoclays for industrial waste water as well as potable water treatment to make further step into green environment. A little amount of nanoclay can alter the entire properties of polymers, paints, inks and greases to a great extent by dispersing 1nm thick layered silicate throughout the matrices. The flexibility of interlayer spacing of layered silicates accommodates therapeutic agents which can later on be released to damaged cell. Because the release of drugs in drug-intercalated layered materials is controllable, these new materials have a great potential as a delivery host in the pharmaceutical field. The problem of clean water can be solved by treating industrial and municipal waste water with organoclays in combination with other sorbents like activated carbon and alum. Organoclays have proven to be superior to any other water treatment technology in applications where the water to be treated contains substantial amounts of oil and grease or humic acid.
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