The puzzling origin of lymphocytes

Sanford-Burnham Medical Research Institute.
Blood (Impact Factor: 9.78). 06/2012; 119(24):5609-10. DOI: 10.1182/blood-2012-04-420737
Source: PubMed
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    ABSTRACT: Erythro-myeloid progenitors (EMP) serve as a major source of hematopoiesis in the developing conceptus prior to the formation of a permanent blood system. In this review, we summarize the current knowledge regarding the emergence, fate, and potential of this hematopoietic stem cell (HSC)-independent wave of hematopoietic progenitors, focusing on the murine embryo as a model system. A better understanding of the temporal and spatial control of hematopoietic emergence in the embryo will ultimately improve our ability to derive hematopoietic stem and progenitor cells from embryonic stem cells and induced pluripotent stem cells to serve therapeutic purposes.
    Blood Cells Molecules and Diseases 10/2013; 51(4). DOI:10.1016/j.bcmd.2013.09.006 · 2.33 Impact Factor