Article

MRI findings of neuro-Behcet’s disease

Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Neurology, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Neurology, School of Medicine, Saint Louis University, Saint Louis, MO, USA; Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Neurology and Psychiatry, Saint Louis University, 1438 Monteleone Hall, South Grand Boulevard, Saint Louis, MO 63104, USA
Clinical Rheumatology (impact factor: 2). 04/2012; 30(6):765-770. DOI:10.1007/s10067-010-1650-9 pp.765-770

ABSTRACT Neurological manifestations present in 5% to 30% of patients with Behçet’s disease. We studied consecutive patients with relapsing–remitting
or progressive neuro-Behcet’s disease who referred from January 2002 to January 2009 to Nemazee Hospital, Shiraz, southern
Iran. Sequential MRIs were performed during clinical relapses in patients with relapsing–remitting course or during relentless
progression after first referral of patients with progressive course. We reviewed 55 MRIs of 17 patients (ten men and seven
women) with age of 36.4 ± 8.1years at the time of first MRI. Nine (53%) patients had a relapsing–remitting course and eight
(47%) had a progressive course. The initial and last follow-up studies had a mean interval of 29.2months (range, 24 to 84).
Of the patients with progressive neuro-Behcet’s disease, 50% had brainstem atrophy and 75% had black holes in their last follow-up
MRIs. The respective prevalence rates for those with relapsing–remitting neuro-Behcet’s disease were 0% and 11%. In the total
population of patients with neuro-Behcet’s disease, the number of lesions (p = 0.002) and MRI burden (p = 0.016) had a significant increase in the last follow-up studies in comparison to the initial studies. Incremental pattern
in the number of lesions and MRI burdens in patients with parenchymal neuro-Behcet’s disease in our longitudinal study may
imply an ongoing pathologic process.

KeywordsBehcet syndrome–Central nervous system–MRI–Neuro-Behcet disease–Neuro-Behcet’s disease

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Keywords

17 patients
 
Behçet’s disease
 
clinical relapses
 
consecutive patients
 
first MRI
 
initial studies
 
KeywordsBehcet syndrome–Central nervous system–MRI–Neuro-Behcet disease–Neuro-Behcet’s disease
 
last follow-up studies
 
longitudinal study
 
MRI burden
 
MRI burdens
 
Nemazee Hospital
 
neuro-Behcet’s disease
 
ongoing pathologic process
 
parenchymal neuro-Behcet’s disease
 
progressive course
 
progressive neuro-Behcet’s disease
 
relapsing–remitting neuro-Behcet’s disease
 
respective prevalence rates
 
Sequential MRIs