Preparation of chiral pyrrole derivatives by the Paal-Knorr reaction

Chemistry of Heterocyclic Compounds (Impact Factor: 0.62). 05/2011; 47(2):182-193. DOI: 10.1007/s10593-011-0739-7


A new approach has been developed for the synthesis of N-alkylpyrroles with a chiral substituent at the nitrogen atom by the
Paal-Knorr reaction using esters of amino acids as the source of chirality.

Keywords1,4-dicarbonyl compounds–2,5-dimethyl- and 5-aryl-2-methylpyrroles with a chiral substituent at the nitrogen atom–chiral pyrrole derivatives–iodine-catalyzed cyclization–Paal-Knorr method–Stetter reaction

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