Dexmedetomidine for short-term and long-term sedation: amplifying its applicability

Critical Care (Impact Factor: 4.93). 01/2005; 9:1-1. DOI: 10.1186/cc3660
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Rhabdomyolisis most commonly occurs after muscle injury, alcohol ingestion, drug intake and exhaustive exercise. Prolonged muscle compression at the time of surgery may produce this complication. Obesity has been reported as a risk factor for pressure-induced rhabdomyolysis, but no reports associated with bariatric surgery could be found in the literature. We report 3 superobese patients who developed rhabdomyolysis after bariatric surgery. This complication was attributed to direct and prolonged pressure of the bed against the dorsal and gluteal muscles.
    Obesity Surgery 05/2003; 13(2):297-301. · 3.10 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: IMPLICATIONS: Dexmedetomidine, an alpha(2)-adrenoceptor agonist, is indicated for sedating patients on mechanical ventilation. It has been approved by the Food and Drug Administration for 24-h use. This is a report concerning a patient in whom a continuous infusion of dexmedetomidine was safely used for a week to help in averting frank withdrawal symptoms from an opioid and benzodiazepines.
    Anesthesia & Analgesia 05/2003; 96(4):1054-5, table of contents. · 3.30 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: To determine whether central venous pressure measurements taken from a peripherally inserted central catheter (PICC) correlate with those from a centrally inserted central catheter (CICC). A pilot bench study followed by a prospective, non-blinded, clinical comparison. A 16-bed medical coronary intensive care unit and a 30-bed surgical intensive care unit at a university hospital. Seven surgical intensive care unit patients and five medical coronary intensive care unit patients. During the bench study, a simple manometer system was set up to test the catheters. During the clinical study, measurements of central venous pressure were recorded from patients who had an indwelling CICC and PICC concomitantly. Positions of the catheter tips in the chest were verified by radiography. Paired central venous pressure measurements were taken from 19-gauge dual-lumen PICCs and from 7-Fr, 16-gauge, 18-gauge, and pulmonary artery catheter CICCs, all with continuous pressure infusion devices. Bench work showed that PICCs, because of their longer length and narrower lumen, have a higher inherent resistance, which can be overcome with a continuous infusion device. During the clinical study, three to 12 paired, digital, central venous pressure measurements were recorded from each of 12 patients for a total of 77 data pairs. Measurements were recorded at end-expiration. Mean central venous pressure from the CICCs was 11 + 7 mm Hg, and from the PICCs was 12 + 7 mm Hg. PICC pressure versus CICC pressure correlated (r = 0.99) for all data pairs. Analysis by repeated measures showed PICC central venous pressure more than CICC central venous pressure by 1.0 + 3.2 mm Hg (p = 0.02). PICCs can be used to measure central venous pressure and to follow trends in a clinical setting when used with a pressure infusion device to overcome the natural resistance of the PICC. Central venous pressure recorded via PICCs is slightly higher, but the difference is clinically insignificant.
    Critical Care Medicine 01/2001; 28(12):3833-6. · 6.12 Impact Factor

Full-text (2 Sources)

Available from
May 22, 2014