Article

Palladium-catalyzed sequential formation of C-C bonds: efficient assembly of 2-substituted and 2,3-disubstituted quinolines.

School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China.
Angewandte Chemie International Edition (impact factor: 13.45). 06/2012; 51(29):7292-6. DOI:10.1002/anie.201202412
Source: PubMed

ABSTRACT A series of substituted quinolines was prepared from arylamines, aldehydes, and terminal olefins (see scheme). The palladium-catalyzed sequential formation of C-C bonds proceeds smoothly with both electron-deficient and electron-rich olefins. When acrylic acid is used as terminal olefin, decarboxylation occurs to provide 2-substituted quinolines.

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Keywords

acrylic acid
 
arylamines
 
C-C bonds proceeds
 
decarboxylation
 
palladium-catalyzed sequential formation
 
terminal olefin
 
terminal olefins
 

Xiaochen Ji