Medicinal solutions for injection are frequently applied in anthroposophic medicine and homeopathy. Despite their extensive use, there is little data published on the safety of these products. Therefore, we investigated the safety of anthroposophic and homeopathic solutions for injection through a systematic evaluation of adverse drug reactions (ADRs).
ADRs were extracted from the pharmacovigilance databases of eight German manufacturers. Analysed ADRs included case reports in humans only, (spontaneous) case reports from post-marketing surveillance, literature and clinical/safety trials.
Between 2000 and 2009, in total, 303 million ampoules for injection were sold, and 486 case reports were identified, corresponding to a total number of 1180 ADRs. Of all case reports, 71.8% (349/486) included ADRs that were listed (e.g. stated in package leaflet), and 9.5% (46/486) of the reports were classified as serious. The most frequently reported ADRs were pruritus, followed by angioedema, diarrhoea and erythema. A total of 27.3% (322/1180) were localized reactions for example; application or injection site erythema, pain, swelling and inflammation. The overall reporting rate of ADRs associated with injections was less than 4 per 1 million sold ampoules and classified as very rare.
Our systematic evaluation demonstrated that the reporting rate of ADRs associated with anthroposophic and homeopathic solutions for injection is very low. Most reported ADRs were listed, and one quarter consisted of local reactions. These findings suggest a low risk profile for solutions for injection as therapeutically applied in anthroposophic medicine and homeopathy.
"In this study, adverse reactions to AM treatment were infrequent and mostly of mild-to-moderate intensity. This confirms findings from other prospective studies
[7,65-68] as well as retrospective surveys
 and pharmacovigilance databases
. Also, the high level of patient satisfaction with AM treatment in this study is in keeping with other studies
[Show abstract][Hide abstract] ABSTRACT: Anthroposophic treatment includes special artistic and physical therapies and special medications. We here report an update to a previously published study of anthroposophic treatment for chronic diseases, including more patients and a longer follow up. The Anthroposophic Medicine Outcomes Study (AMOS) was a prospective observational cohort study of anthroposophic treatment for chronic indications in routine outpatient settings in Germany. Anthroposophic treatment was associated with improvements of symptoms and quality of life. Previous follow-up-analyses have been performed after 24 months or, in subgroups of patients enrolled in the period 1999-2001, after 48 months. We conducted a 48-month follow-up analysis of all patients enrolled in AMOS in the period 1999-2005.
1,510 outpatients aged 1-75 years, starting anthroposophic treatment for chronic conditions in routine German outpatient settings, participated in a prospective cohort study. Main outcomes were Symptom Score (primary outcome, mean symptom severity on numerical rating scales), SF-36 Physical and Mental Component scores in adults, and disease-specific outcomes in the six most common diagnosis groups: asthma, anxiety disorders and migraine (numerical rating scales), depression (Center for Epidemiological Studies Depression Scale), attention deficit hyperactivity symptoms (FBB-HKS Total score), and low back pain (Hanover Functional Ability Questionnaire, Low Back Pain Rating Scale).
Median disease duration at baseline was 3.5 years. From baseline to 48-month follow-up all ten outcomes improved significantly (p < 0.001 for all pre-post comparisons). Standardised Response Mean effect sizes were large (range 0.84-1.24 standard deviations) for seven comparisons, medium for two comparisons (SF-36 Mental Component: 0.60, Low Back Pain Rating Scale: 0.55), and small for one comparison (SF-36 Physical Component: 0.39). Symptom Score improved significantly with large effect sizes in adults and children, and in the four main anthroposophic therapy modality groups (art therapy, eurythmy therapy, rhythmical massage therapy, medical therapy).
This 48-month follow-up analysis confirmed previous analyses from the AMOS study. Outpatients receiving anthroposophic treatment for chronic indications had sustained, clinically relevant improvements of symptoms and quality of life.
BMC Research Notes 07/2013; 6(1):269. DOI:10.1186/1756-0500-6-269
[Show abstract][Hide abstract] ABSTRACT: RationaleNo data exist on the percentage of licensed nurses in Sweden who practise a form of complementary and alternative medicine (CAM).Objective
To investigate the use, practice, perception and knowledge of CAM among a representative sample of licensed nurses in Sweden.MethodsA cross-sectional descriptive anonymous survey on CAM-related issues was distributed between April and June 2012 to 1200 licensed nurses who were member of the Swedish Association of Health Professionals (Vårdförbundet).ResultsA total of 335 nurses (28%) responded to the survey of which 83% reported to have used at least one CAM method for self-care. Massage (59.7%), dietary supplements (51.3%) and mind–body therapies (24.8%) were most frequently used. CAM practice was reported by 11 and 43% of the nurses wished to practise a CAM method in the future. Main barriers for practise of CAM were lack of knowledge, lack of scientific evidence and little knowledge on legislative issues concerning CAM. A high proportion (73%) of nurses never or seldom asked patients about CAM use although 59.1% opined that health-care personnel should inform clients about CAM when they ask for it. Having knowledge about CAM was found to be significantly (p < 0.05) associated with a higher odds of respondents to ask their patients about CAM use (OR 3.3; CI 1.4–7.6). Similar findings on CAM use, knowledge and perception were observed in a confirmatory analysis among an additional convenience sample of 625 nurses in Sweden.Conclusion
Licensed nurses in Sweden seemed to have an overall positive attitude towards CAM. Although CAM practice was low, a substantial number wished to practise a CAM method in the future. Main barrier for CAM practise and communication was lack of knowledge and evidence, emphasizing the need for structural education, information and research on CAM in Sweden.
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.