Spherical molecularly imprinted polymer particles for bisphenol A (BPA-MIP) were easily prepared by using a Y-junction microfluidic device. The sizes of the obtained BPA-MIP particles were found to be 86 µm with a narrow size distribution. The binding characteristics were investigated by drawing a binding isotherm to estimate the binding constant and by switching the polarity of solvents to examine the feasibility of use as a medium for affinity chromatography. When dichloromethane was used as a solvent, BPA was strongly bound to the spherical BPA-MIP particles based on hydrogen bond formation; after switching the solvent to methanol, BPA was eluted quantitatively due to the weakening of the hydrogen bonding, suggesting that the spherical BPA-MIP particles can be applied to affinity-type solid-phase extraction for BPA. As the present method can provide a diverse range of spherical MIPs without tedious procedures, MIP-based affinity media will be able to be more readily used as pretreatment and/or purification for various fields.
[Show abstract][Hide abstract] ABSTRACT: A simple and fast method for both dummy template selection and polymer composition optimization is proposed here. A series of dummy templates for bisphenols imprinting were screened by running them on a non-imprinted polymer (NIP) column with porogen solvent as mobile phase. The tested dummy templates mainly involved bisphenol S (BPS), bromobisphenol A (TBBPA), bisphenol F (BPF), bisphenol E (BPE), bisphenol B (BPB), bisphenol AF (BPAF), 2,2',6,6'-tetramethyl-4,4'-sulfonyldiphenol (BS-TM) and 4,4'-diaminodiphenylmethane (DADPM). Different monomers and porogens were also investigated for BPS and DADPM using the same method. BPS dummy template was finally selected with acetonitrile and 4-VP as porogen and monomer. The resulting dummy molecularly imprinted polymer (DMIP) achieved superior affinities for BPF, BPE, BPA, BPB and BPAF with imprinting factors 14.5, 13.8, 8.7, 5.7 and 4.2, respectively. An efficient method based on BPS-DMIP-SPE coupled with HPLC-UV was developed for selective extraction of BPF, BPE, BPA, BPB and BPAF in water samples. The method showed excellent recoveries (89.4-102.0%) and precision (RSD 0.3-4.8%, n=5) for tap and river water samples spiked at three concentration levels each (40, 200 and 1000ngL(-1)). The detection limits ranged between 2.2 and 3.8ngL(-1) with a sample volume of 500mL. The result demonstrated the superiority of the optimized method for selective extraction of BPs in water samples at the ngL(-1) level.
Journal of Chromatography A 03/2014; 1343. DOI:10.1016/j.chroma.2014.03.063 · 4.17 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Surface molecularly imprinted polypropylene-based fibers for specifically recognizing bisphenol A (BPA-MIF) have been prepared through non-covalent surface molecular imprinting and self-assembly post-polymerization techniques. Acrylic acid (AA) was grafted onto pre-irradiated polypropylene (PP) fiber, and then polyethyleneimine (PEI) was assembled onto the AA grafted fiber surface to introduce amine groups for binding BPA templates from its aqueous solution. The imprinted binding sites were stabilized by cross-linking with glutaraldehyde in the presence of BPA templates. The Scatchard analysis indicated that two classes of amine binding sites were formed in the imprinted fiber BPA-MIF. The maximum adsorption capacity and association constant were 85.9 μmol/g and 56.1 μmol/L, respectively. The selectivity of BPA-MIF fibers for BPA against its analogues was obviously increased by adopting the surface molecular imprinting technique. In this work, a new path was given for the preparation of molecular imprinting materials in water system for other toxics with low solubility in aqueous solution. Figure A surface molecularly imprinted fiber for BPA was prepared by grafting acrylic acid onto polypropylene fiber, subsequently reacting with polyethylenimine to introduce amine to bind BPA templates from its aqueous solution and cross-linking with glutaraldehyde to stabilize the binding sites. The selectivity of the resulting fiber for BPA against its analogues was obviously increased after adopting the imprinting technique.
Journal of Polymer Research 06/2014; 21(6). DOI:10.1007/s10965-014-0468-6 · 1.92 Impact Factor
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