Novel cause of sudden cardiac death: IgG4-related disease.
Department of Pathology, The Johns Hopkins Hospital, 600 N Wolfe St, Pathology Bldg, Room 401, Baltimore, MD 21287, USA.Circulation (Impact Factor: 15.2). 06/2012; 125(23):2956-7. DOI: 10.1161/CIRCULATIONAHA.111.061002
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ABSTRACT: An 81-year-old woman with history of thyroiditis and a putative diagnosis of retroperitoneal fibrosis presented with abdominal pain, progressive shoulder pain, back pain, and lower extremity weakness. Abdominal and pelvic MRI revealed periaortic inflammation and a left renal mass, which were F-FDG avid on PET/CT. Renal biopsy was compatible with immunogammaglobulin 4 (IgG4)-related disease. Total spine MRI revealed postcontrast meningeal enhancement, correlating with FDG activity. Epidural biopsy showed chronic inflammation and scattered but not abnormal IgG4-positive cells, possibly related to posttreatment changes. This case exemplifies multiorgan involvement in IgG4-related disease.Clinical nuclear medicine 06/2014; 39(6):537-9. · 3.92 Impact Factor
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