Article

IL-18 serum concentration is markedly elevated in acute EBV infection and can serve as a marker for disease severity.

Department of Medicine, Radboud University Nijmegen Medical Centre, and Nijmegen Institute for Infection, Inflammation and Immunity (N4i), Nijmegen, The Netherlands.
The Journal of Infectious Diseases (impact factor: 6.41). 06/2012; 206(2):197-201. DOI:10.1093/infdis/jis335
Source: PubMed

ABSTRACT Epstein Barr virus (EBV)-related diseases encompass both acute infections that result in acute infectious mononucleosis and chronic infections that result in lymphoproliferative malignant diseases. While classical inflammatory parameters such as C-reactive protein (CRP) have proven their usefulness during bacterial and fungal infections, they are often low and nondiscriminatory in viral infections. Here, we show that IL-18 is markedly elevated during acute EBV infections and EBV-associated diseases, while ferritin concentrations are also elevated during acute EBV infection and correlate with IL-18. Therefore, IL-18 and ferritin may represent infection markers for viral infections such as EBV, similar to CRP for bacterial infections.

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Keywords

acute EBV infection
 
acute EBV infections
 
acute infections
 
acute infectious mononucleosis
 
bacterial infections
 
C-reactive protein
 
chronic infections
 
classical inflammatory parameters
 
Epstein Barr virus
 
ferritin
 
ferritin concentrations
 
fungal infections
 
lymphoproliferative malignant diseases
 
nondiscriminatory
 
usefulness
 
viral infections