"Prior research, however, shows that although the oxygen affinity of haemoglobin S is decreased in its polymerised state and in hypoxic conditions, it is near normal in its tetrameric state and in patients in normoxia (Abdu et al., 2008; Fabry et al., 2001), like the steady state SCA patients in our study. In children, lower peripheral oxygen saturation was positively correlated with cerebral desaturation (Quinn and Dowling, 2012). In adults, however, when the oxygen saturation of venous blood of HbSS patients was directly tested, it was found to be similar to that of HbAA controls, probably because increased blood flow in SCA leads to relatively lower oxygen extraction (Gladwin et al., 1999). "
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