Low dose macrolide administration for long term is effective for otitis media with effusion in children.

Department of Otorhinolaryngology, the First Affiliated Hospital, Institute of Otorhinolaryngology, Sun Yat-Sen University, Guangzhou 510080, PR China.
Auris, nasus, larynx (Impact Factor: 0.58). 06/2012; DOI: 10.1016/j.anl.2012.05.008
Source: PubMed

ABSTRACT OBJECTIVE: To explore the clinical effect and possible mechanism of macrolides on otitis media with effusion in children. METHODS: Children with otitis media with effusion were recruited and prescribed for macrolides according to a designed scheme, and followed up for 8-12 weeks. Middle ear effusion samples were collected from the participants to assess the presence of biofilm. RESULTS: Macrolides were found to have significant effect on the therapy of early stage otitis media with effusion for 88.7-92.5% of participants compared with 50.9-60.3% in control group after 8-12 weeks. Almost 72.1% of chronic otitis media with effusion patients recovered after an 8 weeks' course low dose macrolides prescription. Biofilm occurred in 30.8% (4/13) of middle ear effusion. CONCLUSIONS: The results indicate that macrolides are effective for otitis media with effusion in children. Bacterial biofilm may play an important role in the pathogenesis of otitis media with effusion.