Article

Leveraging kinase inhibitors to develop small molecule tools for imaging kinases by fluorescence microscopy.

Department of Chemistry, University of Massachusetts Boston, Boston, MA 02125, USA.
Molecular BioSystems (impact factor: 3.53). 06/2012; 8(10):2523-6. DOI:10.1039/c2mb25099c pp.2523-6
Source: PubMed

ABSTRACT As the usage of fluorescence microscopy as a tool to study biological systems continues to grow, so does the need for additional tools that permit the selective detection of proteins of interest. Existing selective and well-characterized kinase inhibitors may be exploited to develop novel small molecule probes useful in imaging kinases by fluorescence microscopy.

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Keywords

additional tools
 
Existing selective
 
fluorescence microscopy
 
imaging kinases
 
novel small molecule probes useful
 
proteins
 
selective detection
 
well-characterized kinase inhibitors