Mucormycosis after allogeneic haematopoietic stem cell transplantation: A French Multicentre Cohort Study (2003-2008)

Service d'Hématologie- Greffe, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris  Université Paris-Diderot, Sorbonne Cité, Paris  Service des Maladies infectieuses et Tropicales, Centre d'Infectiologie Necker Pasteur, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris  Centre National de Référence Mycologie et Antifongiques, Institut Pasteur, Paris  Département de Bioinformatique Médicale, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris  Unité de Parasitologie-Mycologie, Laboratoire de Microbiologie, HEGP, Assistance Publique-Hôpitaux de Paris, Paris  Service de Pneumologie, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris  Service d'Hématologie, Centre Hospitalier Universitaire Nancy, Nancy  Service de Parasitologie-Mycologie, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris  Département d'Oncologie et d'Hématologie, Hôpitaux Universitaires de Strasbourg, Strasbourg  Service d'Hématologie, Centre Hospitalier Universitaire, Besançon,  Service d'Hématologie, Centre Hospitalier Universitaire Nantes, Nantes  Service d'Hématologie, Centre Hospitalier Universitaire Lyon, Lyon  Service d'Hématologie, Hôpital Henri-Mondor, Assistance Publique-Hôpitaux de Paris, Créteil, et Université Paris-Est, Créteil  Service d'Hématologie, Hôpital Saint-Antoine, Assistance Publique-Hôpitaux de Paris, Paris  Service d'Hématologie, Centre Hospitalier Universitaire Saint-Etienne, Saint-Etienne  Service de Pneumologie, Hôpital Foch, Suresnes and  Service d'Hématologie, Centre Hospitalier Universitaire Bordeaux, Bordeaux, France.
Clinical Microbiology and Infection (Impact Factor: 5.77). 05/2012; 18(10):E396-E400. DOI: 10.1111/j.1469-0691.2012.03908.x
Source: PubMed


Clin Microbiol Infect 2012; 18: E396-E400 ABSTRACT: We conducted a nationwide retrospective study to evaluate clinical characteristics and outcome of mucormycosis among allogeneic haematopoietic stem cell transplant recipients. Twenty-nine patients were diagnosed between 2003 and 2008. Mucormycosis occurred at a median of 225 days after allogeneic haematopoietic stem cell transplant, and as a breakthrough infection in 23 cases. Twenty-six patients were receiving steroids, mainly for graft-versus-host disease treatment, while ten had experienced a prior post-transplant invasive fungal infection. Twenty-six patients received an antifungal treatment; surgery was performed in 12. Overall survival was 34% at 3 months and 17% at 1 year.

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Available from: Raoul Herbrecht, Jan 21, 2015
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