Article

Long-term oncological and continence outcomes after laparoscopic radical prostatectomy: a single-centre experience

Department of Urology, Charité University Medicine Berlin Berlin Institute for Urological Research, Berlin Department of Urology, University Teaching Hospital, Offenbach, Germany.
BJU International (Impact Factor: 3.13). 06/2012; 110(11C). DOI: 10.1111/j.1464-410X.2012.11279.x
Source: PubMed

ABSTRACT OBJECTIVE To investigate biochemical recurrence (BCR) rates and data on postoperative incontinence in a large laparoscopic radical prostatectomy (LRP) cohort with extended follow-up. MATERIALS AND METHODS BCR and independent predictors of BCR were identified using Kaplan-Meier and Cox regression analysis of 1845 patients who underwent LRP from 1999 to 2007. Urinary incontinence was evaluated by pads per day and stratified as follows: 0-1 pad: no incontinence; 2-3 pads: mild incontinence; and >= 3 pads: severe incontinence. RESULTS Organ-confined disease, extraprostatic extension, seminal vesicle invasion and lymph node metastasis were present in 71.3%, 20.5%, 6.7% and 3.2% of patients, respectively. The positive surgical margin rate was 29.2%. Postoperatively, 74.9% of the patients were continent, while 9.2% had mild and 15.9% severe incontinence. The mean follow-up was 5 years with a maximum follow-up of 11.3 years. There were 51 overall deaths and six deaths from prostate cancer. The 5-year, 8-year and 10-year BCR-free survival rates were 83.9%, 78.6% and 75.6%, respectively. On univariate analyses preoperative D'Amico risk classification, pathological tumour stage, postoperative Gleason sum and surgical margin status were predictors of BCR (P < 0.001). On multivariable analysis, D'Amico classifi cation, Gleason sum (P < 0.001), postoperative tumour stage (P < 0.001), nodal status (P < 0.001) and surgical margin status (P = 0.002) were independent predictors of BCR. CONCLUSIONS LRP offers excellent long-term functional and oncological results with a low incidence of BCR for patients with localized disease. These results could be used for patient counselling before robot-assisted laparascopic prostatectomy (RALP) until long-term follow-up data for RALP is available.

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