Water-Soluble Conjugated Polymers for Imaging, Diagnosis, and Therapy

Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China.
Chemical Reviews (Impact Factor: 45.66). 06/2012; 112(8):4687-735. DOI: 10.1021/cr200263w
Source: PubMed

ABSTRACT Water-soluble conjugated polymers (WSCP) for imaging, diagnosis, and therapy, and the progress in the recent 5 years, from 2007 to 2011, is discussed. Liu and co-workers synthesized α-mannose and β-glucose containing PTs and PFPs. To overcome the relative instability of liquid-phase PDA sensors, Park and co-workers developed a solid-phase chip based on streptavidin-functionalized PDA liposome for the diagnosis of pathogen infection. Shi and co-workers reported the detection of glutathione (GSH) using cationic PT 72 in both colorimetric and fluorescent methods. Chiu and co-workers modified the carboxyl-functionalized ultrabright PFBT CPNs with STA and IgG to perform specific cell imaging. Whitten and co-workers compared the differences regarding the light and dark biocidal activity between cationic PPEs and a cationic PPE alternative.

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