Article

Anti-inflammatory activity of flavonoids fromPopulus davidiana

Archives of Pharmacal Research (impact factor: 1.59). 04/2012; 29(12):1102-1108. DOI:10.1007/BF02969299 pp.1102-1108

ABSTRACT Anin vitro bioassay-guide revealed that the methanol (MeOH) extract of the stem bark ofPopulus davidiana showed considerable inhibitory activity against cyclooxygenase (COX-1, COX-2). Continuous phytochemical study of the MeOH
extract of this plant led to the isolation of ten flavonoids; sakuranetin (1), rhamnocitrin (2), 7-O-methylaromadendrin (3), naringenin (4), eriodictyol (5), aromadendrin (6), kaempferol (7), neosakuranin (8), sakuranin (9) and sakurenetin-5,4′-di-β-D-glucopyranoside (10). Their structures were identified on the basis of their physicochemical and spectroscopic analyses. The isolated compounds,1–10, were tested for their inhibitory activities against COX-1 and COX-2. Compound7 was found to have potent inhibitory effect on COX-1 and a moderate effect on COX-2, meanwhile, compounds1–6 showed moderate inhibition against COX-1 only. Moreover, compounds5–8 exhibited suppressive effects on xanthine oxidase (XO). These results may explain, in part, the traditional uses ofP. davidiana in ethnomedicine.

0 0
 · 
0 Bookmarks
 · 
40 Views
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

Anin vitro bioassay-guide
 
Compound7
 
compounds1–6
 
compounds5–8 exhibited suppressive effects
 
considerable inhibitory activity
 
Continuous phytochemical study
 
COX-1
 
COX-2
 
inhibitory activities
 
moderate effect
 
naringenin
 
neosakuranin
 
potent inhibitory effect
 
sakuranin
 
sakurenetin-5,4′-di-β-D-glucopyranoside
 
spectroscopic analyses
 
stem bark ofPopulus davidiana
 
traditional
 
xanthine oxidase
 
XO